Sökning: onr:"swepub:oai:DiVA.org:uu-457346" >
The multifaceted PD...
The multifaceted PDCD10/CCM3 gene
-
- Valentino, Mariaelena (författare)
- FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy.
-
- Dejana, Elisabetta (författare)
- Uppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy.;Univ Milan, Dept Oncol & Haematooncol, I-20122 Milan 7, Italy.
-
- Malinverno, Matteo (författare)
- FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy.
-
FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy Vaskulärbiologi (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
-
Ingår i: Genes & Diseases. - : Elsevier. - 2352-4820 .- 2352-3042. ; 8:6, s. 798-813
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-related gene, although it is now usually known as CCM3, as the third causative gene of cerebral cavernous malformation (CCM). CCM is a neurovascular disease that is characterized by vascular malformations and is associated with headaches, seizures, focal neurological deficits, and cerebral hemorrhage. The PDCD10/CCM3 protein has multiple subcellular localizations and interacts with several multi-protein complexes and signaling pathways. Thus PDCD10/CCM3 governs many cellular functions, which include cell-to-cell junctions and cytoskeleton organization, cell proliferation and apoptosis, and exocytosis and angiogenesis. Given its central role in the maintenance of homeostasis of the cell, dysregulation of PDCD10/CCM3 can result in a wide range of altered cell functions. This can lead to severe diseases, including CCM, cognitive disability, and several types of cancers. Here, we review the multifaceted roles of PDCD10/CCM3 in physiology and pathology, with a focus on its functions beyond CCM. Copyright (C) 2021, Chongqing Medical University. Production and hosting by Elsevier B.V.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Cancer
- Cell signaling
- Cell-cycle
- Neurovascular unit
- PDCD10/CCM3
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas