Ultrasound-Responsive Smart Drug Delivery System of Lipid Coated Mesoporous Silica Nanoparticles

Amin, Muhammad UmairDept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany. (författare)

The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid supported mesoporous silica nanoparticles (MSNPs) for triggered drug release at the target site and simultaneously avoiding the premature release. MSNPs with a higher drug loading capacity and very slow release were designed so as to enhance release by FDA approved US-irradiation. Doxorubicin, as a model drug, and perfluoropentane (PFP) as a US responsive material, were entrapped in the porous structure of MSNPs. Lipid coating enhanced the cellular uptake and in addition provided a gatekeeping effect at the pore opening to reduce premature release. The mechanical and thermal effects of US induced the conversion of liquid PFP to a gaseous form that was able to rupture the lipid layer, resulting in triggered drug release. The prolonged stability profile and non-toxic behavior made them suitable candidate for the delivery of anticancer drugs. This smart system, with the abilities of better cellular uptake and higher cytotoxic effects on US-irradiation, would be a good addition to the applied side of chemotherapeutic advanced drug delivery systems.

Ali, SajidUppsala universitet,Fysikalisk kemi,Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany(Swepub:uu)sajal906 (författare)
Tariq, ImranDept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.;Univ Punjab, Coll Pharm, Lahore 54000, Pakistan. (författare)
Ali, Muhammad YasirDept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.;GC Univ Faisalabad, Fac Pharmaceut Sci, Faisalabad 38000, Pakistan. (författare)
Pinnapreddy, Shashank ReddyDept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany. (författare)
Preis, EduardDept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany. (författare)
Woelk, ChristianUniv Leipzig, Fac Med, Inst Pharm Pharmaceut Technol, Eilenburger Str 15a, D-04317 Leipzig, Germany. (författare)
Harvey, Richard D.Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria. (författare)
Hause, GerdMartin Luther Univ Halle Wittenberg, Bioctr, Weinbergweg 22, D-06120 Halle, Germany. (författare)
Bruessler, JanaDept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany. (författare)
Bakowsky, UdoDept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany. (författare)
Dept Pharmaceut & Biopharmaceut, Univ Marburg, Robert Koch Str 4, D-35037 Marburg, Germany.Fysikalisk kemi (creator_code:org_t)

Av författaren/redakt...: Amin, Muhammad U ...; Ali, Sajid; Tariq, Imran; Ali, Muhammad Ya ...; Pinnapreddy, Sha ...; Preis, Eduard; visa fler...; Woelk, Christian; Harvey, Richard ...; Hause, Gerd; Bruessler, Jana; Bakowsky, Udo; visa färre...

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