SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-457886"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-457886" > Associations of vas...

Associations of vascular and bone status in arthritis patients

Pusztai, Anita (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Hamar, Attila (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Czokolyova, Monika (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
visa fler...
Gulyas, Katalin (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Horvath, Agnes (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Vegh, Edit (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Petho, Zsofia (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Szamosi, Szilvia (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Balogh, Emese (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.;St Vincents Univ Hosp, Ctr Arthrit & Rheumat Dis, Dublin, Ireland.
Bodnar, Nora (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Bodoki, Levente (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Szentpetery, Agnes (författare)
Uppsala universitet,Reumatologi,Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Bhattoa, Harjit Pal (författare)
Univ Debrecen, Fac Med, Dept Lab Med, Debrecen, Hungary.
Kerekes, Gyorgy (författare)
Univ Debrecen, Fac Med, Dept Internal Med, Debrecen, Hungary.
Juhasz, Balazs (författare)
Univ Debrecen, Fac Med, Dept Oncol, Debrecen, Hungary.
Szekanecz, Eva (författare)
Univ Debrecen, Fac Med, Dept Oncol, Debrecen, Hungary.
Hodosi, Katalin (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Domjan, Andrea (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Szanto, Sandor (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.;Univ Debrecen, Fac Med, Dept Sports Med, Debrecen, Hungary.
Raterman, Hennie G. (författare)
Northwest Clin, Dept Rheumatol, Alkmaar, Netherlands.
Lems, Willem F. (författare)
Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.
Szekanecz, Zoltan (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
Szucs, Gabriella (författare)
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.
visa färre...
Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary Univ Debrecen, Fac Med, Div Rheumatol, Nagyerdei Str 98, H-4032 Debrecen, Hungary.;St Vincents Univ Hosp, Ctr Arthrit & Rheumat Dis, Dublin, Ireland. (creator_code:org_t)
2021-09-30
2021
Engelska.
Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Cardiovascular (CV) disease and osteoporosis (OP) have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Bone and vascular biomarkers and parameters along with the effect of 1-year anti-TNF therapy on these markers were assessed in order to determine correlations between vascular pathophysiology and bone metabolism in RA and AS. Thirty-six patients treated with etanercept or certolizumab pegol and 17 AS patients treated with ETN were included in a 12-month follow-up study. Bone and vascular markers were previously assessed by ELISA. Bone density was measured by DXA and quantitative CT (QCT). Flow-mediated vasodilation (FMD), common carotid intima-media thickness (IMT) and pulse-wave velocity (PWV) were assessed by ultrasound. Multiple correlation analyses indicated associations between bone and vascular markers. Osteoprotegerin, sclerostin and cathepsin K were significantly associated with FMD, IMT and PWV, respectively (p < 0.05). Moreover, total and trabecular BMD determined by QCT inversely correlated with IMT (p < 0.05). On the other hand, among vascular parameters, platelet-derived growth factor BB and IMT correlated with DXA femoral and QCT total BMD, respectively (p < 0.05). In the RM-ANOVA analysis, anti-TNF treatment together with baseline osteocalcin, procollagen 1 N-terminal propeptide (P1NP) or vitamin D3 levels determined one-year changes in IMT (p < 0.05). In the MANOVA analysis, baseline disease activity indices (DAS28, BASDAI), the one-year changes in these indices, as well as CRP exerted effects on multiple correlations between bone and vascular markers (p < 0.05). As the pattern of interactions between bone and vascular biomarkers differed between baseline and after 12 months, anti-TNF therapy influenced these associations. We found a great number of correlations in our RA and AS patients undergoing anti-TNF therapy. Some of the bone markers have been associated with vascular pathophysiology, while some vascular markers correlated with bone status. In arthritis, systemic inflammation and disease activity may drive both vascular and bone disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy