Sökning: onr:"swepub:oai:DiVA.org:uu-458407" > Causal associations...
Fältnamn | Indikatorer | Metadata |
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000 | 07420naa a2200565 4500 | |
001 | oai:DiVA.org:uu-458407 | |
003 | SwePub | |
008 | 211110s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:147906915 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4584072 URI |
024 | 7 | a https://doi.org/10.1093/eurheartj/ehab1702 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1479069152 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ai, Sizhiu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.4 aut |
245 | 1 0 | a Causal associations of short and long sleep durations with 12 cardiovascular diseases :b linear and nonlinear Mendelian randomization analyses in UK Biobank |
264 | c 2021-04-05 | |
264 | 1 | b Oxford University Press,c 2021 |
338 | a print2 rdacarrier | |
520 | a Aims Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences have not been confirmed. We aimed to determine the causal associations between genetically predicted sleep duration and 12 CVDs using both linear and nonlinear Mendelian randomization (MR) designs. Methods and results Genetic variants associated with continuous, short (<= 6 h) and long (>= 9 h) sleep durations were used to examine the causal associations with 12 CVDs among 404 044 UK Biobank participants of White British ancestry. Linear MR analyses showed that genetically predicted sleep duration was negatively associated with arterial hypertension, atrial fibrillation, pulmonary embolism, and chronic ischaemic heart disease after correcting for multiple tests (P <0.001). Nonlinear MR analyses demonstrated nonlinearity (L-shaped associations) between genetically predicted sleep duration and four CVDs, including arterial hypertension, chronic ischaemic heart disease, coronary artery disease, and myocardial infarction. Complementary analyses provided confirmative evidence of the adverse effects of genetically predicted short sleep duration on the risks of 5 out of the 12 CVDs, including arterial hypertension, pulmonary embolism, coronary artery disease, myocardial infarction, and chronic ischaemic heart disease (P< 0.001), and suggestive evidence for atrial fibrillation (P < 0.05). However, genetically predicted long sleep duration was not associated with any CVD. Conclusion This study suggests that genetically predicted short sleep duration is a potential causal risk factor of several CVDs, while genetically predicted long steep duration is unlikely to be a causal risk factor for most CVDs. [GRAPHICS] . | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Short steep duration | |
653 | a Long steep duration | |
653 | a Cardiovascular disease | |
653 | a Mendelian randomization | |
653 | a Linear | |
653 | a Nonlinear | |
700 | 1 | a Zhang, Jihuiu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Southern Med Univ, Sch Clin Med 2, 253 Ind Ave Middle, Guangzhou 510280, Peoples R China.4 aut |
700 | 1 | a Zhao, Guoanu Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.4 aut |
700 | 1 | a Wang, Ningjianu Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Mfg Bur Rd, Shanghai 200011, Peoples R China.4 aut |
700 | 1 | a Li, Guohuau Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.4 aut |
700 | 1 | a So, Hon-Cheongu Chinese Univ Hong Kong, Fac Med,Sch Biomed Sci,Sha Tin Dist, Horse Mat Water,Cheung Res Ctr Management Parkins, Dept Psychiat,KIZ CUHK Joint Lab Bioresources & M, Da Xue Rd, Hong Kong 000000, Peoples R China.4 aut |
700 | 1 | a Liu, Yapingu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut |
700 | 1 | a Chau, Steven Wai-Hou Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut |
700 | 1 | a Chen, Jieu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut |
700 | 1 | a Tan, Xiaou Karolinska Institutet,Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)xzata683 |
700 | 1 | a Jia, Fujunu Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.4 aut |
700 | 1 | a Tang, Xiangdongu Sichuan Univ, State Key Lab Biotherapy,West China Hosp, Sleep Med Ctr,Mental Hlth Ctr, Translat Neurosci Ctr,Dept Resp & Crit Care Med, 37 Guoxue Alley, Chengdu 610041, Peoples R China.4 aut |
700 | 1 | a Shi, Jieu Peking Univ, Peking Univ Hosp 6, Natl Inst Drug Dependence, 38 Xueyuan Rd, Beijing 100191, Peoples R China.4 aut |
700 | 1 | a Lu, Linu Peking Univ, Peking Univ Hosp 6, Natl Inst Drug Dependence, 38 Xueyuan Rd, Beijing 100191, Peoples R China.4 aut |
700 | 1 | a Wing, Yun-Kwoku Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut |
710 | 2 | a Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.b Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Southern Med Univ, Sch Clin Med 2, 253 Ind Ave Middle, Guangzhou 510280, Peoples R China.4 org |
773 | 0 | t European Heart Journald : Oxford University Pressg 42:34, s. 3349-3357q 42:34<3349-3357x 0195-668Xx 1522-9645 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458407 |
856 | 4 8 | u https://doi.org/10.1093/eurheartj/ehab170 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147906915 |
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