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Sökning: onr:"swepub:oai:DiVA.org:uu-459242" > Prognostic role of ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003292naa a2200397 4500
001oai:DiVA.org:uu-459242
003SwePub
008211122s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4592422 URI
0247 a https://doi.org/10.1038/s41416-021-01586-52 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aasebø, Kristine4 aut
2451 0a Prognostic role of tumour-infiltrating lymphocytes and macrophages in relation to MSI, CDX2 and BRAF status :b a population-based study of metastatic colorectal cancer patients
264 c 2021-10-20
264 1b Springer,c 2022
338 a print2 rdacarrier
520 a BACKGROUND: Tumour-infiltrating CD3, CD8 lymphocytes and CD68 macrophages are associated with favourable prognosis in localised colorectal cancer, but the effect in metastatic colorectal cancer (mCRC) is not established.METHODS: A Scandinavian population-based cohort of non-resectable mCRC patients was studied. Tissue microarrays (n = 460) were stained with CD3, CD8 and CD68 using fluorescence-based multiplex immunohistochemistry. Associations with clinicopathological variables, overall survival (OS) and progression-free survival were estimated.RESULTS: Two-thirds of microsatellite instable (MSI) and one-fourth of microsatellite stable (MSS) tumours displayed the highest quartile density of CD8. For CD3 high vs low cases, median OS was 20 vs 16 months (HR: 0.76, 95% CI: 0.59, 0.76, p = 0.025) with 3-year OS of 27 vs 13%. For CD68 high vs low cases, median OS was 23 vs 15 months (HR: 0.69, 95% CI: 0.54, 0.88, p = 0.003) with 3-year OS of 28 vs 12%. MSI, BRAF mutation and CDX2 loss were negative prognostic markers independent of tumour immune infiltration.CONCLUSIONS: In mCRC, high lymphocyte infiltration was found in proportions of MSI and MSS tumours-potential subgroups of immunotherapy response. Tumour-infiltrating CD3 lymphocytes and CD68 macrophages were associated with median and long-term survival. MSI was a significant negative prognostic marker despite high immunogenicity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Bruun, Jarle4 aut
7001 a Bergsland, Christian H4 aut
7001 a Nunes, Luís,d 1995-u Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)luinu972
7001 a Eide, Geir Egil4 aut
7001 a Pfeiffer, Per4 aut
7001 a Dahl, Olav4 aut
7001 a Glimelius, Bengtu Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)bengglim
7001 a Lothe, Ragnhild A4 aut
7001 a Sorbye, Halfdan4 aut
7102 a Uppsala universitetb Experimentell och klinisk onkologi4 org
7730 t British Journal of Cancerd : Springerg 126:1, s. 48-56q 126:1<48-56x 0007-0920x 1532-1827
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459242
8564 8u https://doi.org/10.1038/s41416-021-01586-5

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