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Peritoneal cancer i...
Peritoneal cancer index predicts severe complications after ovarian cancer surgery
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- Lomnytska, Marta, PhD, 1979- (författare)
- Uppsala universitet,Reproduktiv hälsa,Department of Obstetrics and Gynecology, Uppsala University Hospital, 751 85, Uppsala, Sweden
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- Karlsson, Evelina (författare)
- Uppsala universitet,Reproduktiv hälsa,Department of Obstetrics and Gynecology, Gävleborg Regional Hospital, 801 88, Gävle, Sweden
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- Jonsdottir, Björg (författare)
- Uppsala universitet,Reproduktiv hälsa,Department of Obstetrics and Gynecology, Uppsala University Hospital, 751 85, Uppsala, Sweden
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- Lejon, Ann-Marie (författare)
- Department of Obstetrics and Gynecology, Uppsala University Hospital, 751 85, Uppsala, Sweden
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- Stålberg, Karin (författare)
- Uppsala universitet,Reproduktiv hälsa,Department of Obstetrics and Gynecology, Uppsala University Hospital, 751 85, Uppsala, Sweden
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- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa,Department of Obstetrics and Gynecology, Uppsala University Hospital, 751 85, Uppsala, Sweden
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- Silins, Ilvars (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Department of Obstetrics and Gynecology, Uppsala University Hospital, 751 85, Uppsala, Sweden
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- Graf, Wilhelm (författare)
- Uppsala universitet,Gastrointestinalkirurgi
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: European Journal of Surgical Oncology. - : Elsevier. - 0748-7983 .- 1532-2157. ; 47:11, s. 2915-2924
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Abstract
Ämnesord
Stäng
- INTRODUCTION: prediction and importance of severe postoperative complications after ovarian cancer surgery is a strong issue in patient selection and evaluation. Pre- and early peroperative predictors of severe 30-days postoperative complications (Clavien-Dindo class ≥3) after surgery for primary ovarian cancer are not fully established, neither their impact on patients' survival.MATERIALS AND METHODS: A prospective observational study included 256 patients with primary ovarian cancer FIGO stages IIB-IV, operated during 2009-2018 in a primary or interval debulking surgery setting. Patient variables were analysed in relation to severe postoperative complications (Clavien-Dindo class ≥3) and overall survival.RESULTS: High-grade postoperative complications occurred in 24.2% patients. Class 3a complications were observed in 12.5% cases. High-grade complications class ≥3 were observed in 31.6% after primary debulking surgery compared to 12.2% after interval debulking surgery (p = 0.0004). Peritoneal cancer index ≥21 and preoperative albumin concentration ≤33 g/L were independent predictors of high-grade complications. Peritoneal cancer index correlated with the surgical complexity score and completeness of cytoreduction. Increased peritoneal cancer index was a negative predictor of overall survival, but high-grade complications did not influence survival negatively.CONCLUSIONS: Peritoneal cancer index ≥21 was an independent predictor of high-grade complications after ovarian cancer surgery. Increased peritoneal cancer index also impacted overall survival negatively, but high-grade complications did not influence overall survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cytoreduction score
- Ovarian cancer
- Overall survival
- Peritoneal cancer index
- Postoperative complications
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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