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Physiological prope...
Physiological properties, composition and structural profiling of porcine gastrointestinal mucus
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- Barmpatsalou, Vicky (författare)
- Uppsala universitet,Institutionen för farmaci,Swedish Drug Delivery Center
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- Dubbelboer, Ilse R (författare)
- Uppsala universitet,Institutionen för farmaci,Swedish Drug Delivery Center
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- Rodler, Agnes (författare)
- Uppsala universitet,Institutionen för farmaci,Institutionen för läkemedelskemi,Swedish Drug Delivery Center
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- Jacobson, Magdalena (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish Univ Agr Sci, Fac Vet Med & Anim Sci, Dept Clin Sci, POB 7054, SE-75007 Uppsala, Sweden.
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- Karlsson, Eva (författare)
- AstraZeneca, Pharmaceut Technol & Dev Operat, Oral Prod Dev, Gothenburg, Sweden.
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- Pedersen, Betty Lomstein (författare)
- Ferring Pharmaceut AS, Prod Dev & Drug Delivery, Global Pharmaceut R&D, Kay Fiskers Plads 11, DK-2300 Copenhagen, Denmark.
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- Bergström, Christel, 1973- (författare)
- Uppsala universitet,Institutionen för farmaci,Swedish Drug Delivery Center
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(creator_code:org_t)
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- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: European journal of pharmaceutics and biopharmaceutics. - : Elsevier. - 0939-6411 .- 1873-3441. ; 169, s. 156-167
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Abstract
Ämnesord
Stäng
- The gastrointestinal mucus is a hydrogel that lines the luminal side of the gastrointestinal epithelium, offering barrier protection from pathogens and lubrication of the intraluminal contents. These barrier properties likewise affect nutrients and drugs that need to penetrate the mucus to reach the epithelium prior to absorption. In order to assess the potential impact of the mucus on drug absorption, we need information about the nature of the gastrointestinal mucus. Today, most of the relevant available literature is mainly derived from rodent studies. In this work, we used a larger animal species, the pig model, to characterize the mucus throughout the length of the gastrointestinal tract. This is the first report of the physiological properties (physical appearance, pH and water content), composition (protein, lipid and metabolite content) and structural profiling (rheology and gel network) of the porcine gastrointestinal mucus. These findings allow for direct comparisons between the characteristics of mucus from various segments and can be further utilized to improve our understanding of the role of the mucus on region dependent drug absorption. Additionally, the present work is expected to contribute to the assessment of the porcine model as a preclinical species in the drug development process.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
Nyckelord
- Porcine
- Gastrointestinal
- Mucus
- Composition
- Structure
- Proteomics
- Lipidomics
- Rheology
- Cryo-SEM
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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