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Differential regula...
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
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- Vallianatou, Theodosia (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab,Department of Chemistry-BMC, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Lin, Weifeng (författare)
- Uppsala universitet,Kemisk biologi för biomarkörer,Science for Life Laboratory, SciLifeLab
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- Bèchet, Nicholas B (författare)
- Department of Experimental Medical Science, Lund University, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund University, Lund, Sweden
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- Correia, Mario SP (författare)
- Department of Chemistry-BMC, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Shanbhag, Nagesh C (författare)
- Department of Experimental Medical Science, Lund University, Lund, Sweden;Wallenberg Centre for Molecular Medicine, Lund University, Lund University, Lund, Sweden
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- Lundgaard, Iben (författare)
- Department of Experimental Medical Science, Lund University, Lund, Sweden;Wallenberg Centre for Molecular Medicine, Lund University, Lund University, Lund, Sweden
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- Globisch, Daniel (författare)
- Uppsala universitet,Kemisk biologi för biomarkörer,Science for Life Laboratory, SciLifeLab,Analytisk kemi
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(creator_code:org_t)
- 2021-07-22
- 2021
- Engelska.
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Ingår i: Journal of Cerebral Blood Flow and Metabolism. - : Sage Publications. - 0271-678X .- 1559-7016. ; 41:12, s. 3324-3338
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Abstract
Ämnesord
Stäng
- Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of four mouse brain regions and uncovered region-specific circadian variations. Metabolites linked to oxidative stress were altered during sleep including acylcarnitines, hydroxylated fatty acids, phenolic compounds, and thiol-containing metabolites. These findings provide molecular evidence of a significant metabolic shift of the brain energy metabolism. Specific alterations were observed for brain metabolites that have previously not been associated with a circadian function including the microbiome-derived metabolite ergothioneine that suggests a regulatory function. The pseudopeptide beta-citryl-glutamate has been linked to brain development and we have now discovered a previously unknown regioisomer. These metabolites altered by the circadian rhythm represent the foundation for hypothesis-driven studies of the underlying metabolic processes and their function.
Nyckelord
- Brain metabolism
- energy metabolism
- gut-brain axis
- metabolomics
- oxidative stress
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