Sökning: onr:"swepub:oai:DiVA.org:uu-460144" >
Molecular genetic a...
Molecular genetic analysis of neural stem cells after space flight and simulated microgravity on earth
-
- Han, Yilin (författare)
- Uppsala universitet,Kozlova: Regenerativ neurobiologi
-
- Zeger, Lukas (författare)
- Uppsala universitet,Kozlova: Regenerativ neurobiologi
-
- Tripathi, Rekha, PhD student, 1985- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
visa fler...
-
- Egli, Marcel (författare)
- Luzerne School of Engineering and Architecture Institute of Medical Engineering (IMT) Luzerne Switzerland
-
- Ille, Fabian (författare)
- Luzerne School of Engineering and Architecture Institute of Medical Engineering (IMT) Luzerne Switzerland
-
- Lockowandt, Christian (författare)
- Swedish Space Corporation Science Service Division Solna Sweden
-
- Florin, Gunnar (författare)
- Swedish Space Corporation Science Service Division Solna Sweden
-
- Atic, Edvin (författare)
- CELLINK AB Gothenburg Sweden
-
- Redwan, Itedale N. (författare)
- CELLINK AB Gothenburg Sweden
-
- Fredriksson, Robert (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Kozlova, Elena (författare)
- Uppsala universitet,Kozlova: Regenerativ neurobiologi
-
visa färre...
-
(creator_code:org_t)
- 2021-06-22
- 2021
- Engelska.
-
Ingår i: Biotechnology and Bioengineering. - : John Wiley & Sons. - 0006-3592 .- 1097-0290. ; 118:10, s. 3832-3846
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Understanding how stem cells adapt to space flight conditions is fundamental for human space missions and extraterrestrial settlement. We analyzed gene expression in boundary cap neural crest stem cells (BCs), which are attractive for regenerative medicine by their ability to promote proliferation and survival of cocultured and co-implanted cells. BCs were launched to space (space exposed cells) (SEC), onboard sounding rocket MASER 14 as free-floating neurospheres or in a bioprinted scaffold. For comparison, BCs were placed in a random positioning machine (RPM) to simulate microgravity on earth (RPM cells) or were cultured under control conditions in the laboratory. Using next-generation RNA sequencing and data post-processing, we discovered that SEC upregulated genes related to proliferation and survival, whereas RPM cells upregulated genes associated with differentiation and inflammation. Thus, (i) space flight provides unique conditions with distinctly different effects on the properties of BC compared to earth controls, and (ii) the space flight exposure induces postflight properties that reinforce the utility of BC for regenerative medicine and tissue engineering.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Bioengineering
- Biotechnology
- Gene expression
- Hypergravity
- Microgravity
- Neural stem cell
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Han, Yilin
-
Zeger, Lukas
-
Tripathi, Rekha, ...
-
Egli, Marcel
-
Ille, Fabian
-
Lockowandt, Chri ...
-
visa fler...
-
Florin, Gunnar
-
Atic, Edvin
-
Redwan, Itedale ...
-
Fredriksson, Rob ...
-
Kozlova, Elena
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Medicinsk biotek ...
- Artiklar i publikationen
-
Biotechnology an ...
- Av lärosätet
-
Uppsala universitet