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Thalamic dopamine D...
Thalamic dopamine D2-receptor availability in schizophrenia : a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis.
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- Plavén-Sigray, Pontus (författare)
- Karolinska Institute,Copenhagen University Hospital
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- Ikonen Victorsson, Pauliina (författare)
- Karolinska Institute
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- Santillo, Alexander (författare)
- Karolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Matheson, Granville J (författare)
- Karolinska Institute,Karolinska Institutet,Columbia University
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- Lee, Maria (författare)
- Karolinska Institute
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- Collste, Karin (författare)
- Karolinska Institute
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- Fatouros-Bergman, Helena (författare)
- Karolinska Institute,Karolinska Institutet
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- Sellgren, Carl M (författare)
- Karolinska Institute,Karolinska Institutet
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- Erhardt, Sophie (författare)
- Karolinska Institute,Karolinska Institutet
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- Agartz, Ingrid (författare)
- Karolinska Institute,Karolinska Institutet,Diakonhjemmet Hospital,University of Oslo
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- Halldin, Christer (författare)
- Karolinska Institute,Karolinska Institutet
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- Farde, Lars (författare)
- Karolinska Institute,Karolinska Institutet
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- Cervenka, Simon (författare)
- Uppsala University,Karolinska Institute,Karolinska Institutet,Uppsala universitet,Cervenka: Psykiatri
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(creator_code:org_t)
- 2021-11-10
- 2022
- Engelska.
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Ingår i: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 27:2, s. 1233-1240
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [11C]FLB457. The main outcome was D2-R binding potential (BPND) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen's dz = -0.479, p = 0.026, Bayes Factor (BF) > 4). Among subregions, lower BPND was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen's dz = -0.527, p = 0.017, BF > 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen's d = -0.692, p = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Psykiatri
- Psychiatry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Plavén-Sigray, P ...
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Ikonen Victorsso ...
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Santillo, Alexan ...
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Matheson, Granvi ...
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Lee, Maria
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Collste, Karin
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visa fler...
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Fatouros-Bergman ...
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Sellgren, Carl M
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Erhardt, Sophie
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Agartz, Ingrid
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Halldin, Christe ...
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Farde, Lars
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Cervenka, Simon
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Molecular Psychi ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet