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Receptor depletion ...
Receptor depletion and recovery in small-intestinal neuroendocrine tumors and normal tissues after administration of a single intravenous dose of octreotide measured by Ga-68-DOTATOC PET/CT
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- Jahn, Ulrika (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, S-75185 Uppsala, Sweden.
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- Ilan, Ezgi (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Med Phys, Uppsala, Sweden.
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- Velikyan, Irina, 1966- (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden.
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- Fröss-Baron, Katarzyna (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden.
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Med Phys, Uppsala, Sweden.
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- Sundin, Anders, 1954- (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden.
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(creator_code:org_t)
- 2021-11-25
- 2021
- Engelska.
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Ingår i: EJNMMI Research. - : Springer Nature. - 2191-219X. ; 11
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://ejnmmires.sp...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Low-grade neuroendocrine tumors (NETs) are characterized by an abundance of somatostatin receptors (SSTR) that can be targeted with somatostatin analogs (SSA). When activated with a single dose of SSA, the receptor-ligand complex is internalized, and the receptor is by default recycled within 24 h. Ongoing medication with long-acting SSAs at Ga-68-DOTA-SSA-PET has been shown to increase the tumor-to-normal organ contrast. This study was performed to investigate the time-dependent extended effect (7 h) of a single intravenous dose of 400 mu g short-acting octreotide on the tumor versus normal tissue uptake of Ga-68-DOTATOC.Methods: Patients with small-intestinal NETs received a single intravenous dose of 400 mu g octreotide and underwent dynamic abdominal Ga-68-DOTATOC-PET/CT at three sessions (0, 3 and 6 h) plus static whole-body (WB) PET/CT (1, 4 and 7 h), starting each PET/CT session by administering 167 +/- 21 MBq, 23.5 +/- 4.2 mu g (mean +/- SD, n = 12) of Ga-68-DOTATOC. A previously acquired clinical whole-body Ga-68-DOTATOC scan was used as baseline. SUV and net uptake rate K-i were calculated in tumors, and SUV in healthy organs.Results: Tumor SUV decreased significantly from baseline to 1 h post-injection but subsequently increased over time and became similar to baseline at 4 h and 7 h. The tumor net uptake rate, K-i, similarly increased significantly over time and showed a linear correlation both with SUV and tumor-to-blood ratio. By contrast, the uptake in liver, spleen and pancreas remained significantly below baseline levels also at 7 h and the receptor turn-over in tumors thus exceeded that in the normal tissue, with restitution of tumor Ga-68-DOTATOC uptake mainly completed at 7 h. These results however differed depending on tumor size, with significant increases in K-i and SUV between the 1st and 2nd PET, in large tumors (>= 4 mL) but not in small (> 1 to < 4 mL) tumors.Conclusion: SSTR recycling is faster in small-intestinal NETs than in liver, spleen and pancreas. This opens the possibility to protect normal tissues during PRRT by administering a single dose of cold peptide hours before peptide receptor radionuclide therapy (PRRT), and most likely additionally improve the availability and uptake of the therapeutic preparation in the tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Ga-68-DOTATOC
- PET
- CT
- Peptide
- Small-intestinal NET
- Receptor internalization
- SUV
- K-i
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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