Modelling adsorption of proteins and cells on biomimetic hydroxyapatite

• Calcium-deficient hydroxyapatite (CDHA), a biomaterial similar to the inorganic bone matrix, can be used in non-load bearing areas to promote bone regeneration. Upon implantation, CDHA is exposed to blood, leading to serum protein deposition on the surface and enabling cell attachment via membrane-bound receptors. In cell culture studies, biomaterials are often pre-incubated in serum supplemented medium to mimic this process. In this work, to study the extent the protein layer assists in cell adhesion, a Langmuir isotherm-based model for protein and cell adhesion kinetics was used. 

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Materials (hsv//eng)

Nyckelord

In vitro testing

In silico testing

Modelling of material properties

Teknisk fysik med inriktning mot mikrosystemteknik

Engineering Science with specialization in Microsystems Technology

Publikations- och innehållstyp

vet (ämneskategori)

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