Sökning: onr:"swepub:oai:DiVA.org:uu-462602" > Incidence and Morta...
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000 | 04585naa a2200505 4500 | |
001 | oai:DiVA.org:uu-462602 | |
003 | SwePub | |
008 | 211228s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:148667626 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4626022 URI |
024 | 7 | a https://doi.org/10.1053/j.gastro.2021.10.0032 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1486676262 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Holmberg, Dagu Karolinska Institutet4 aut |
245 | 1 0 | a Incidence and Mortality in Upper Gastrointestinal Cancer After Negative Endoscopy for Gastroesophageal Reflux Disease |
264 | 1 | b Elsevier BV,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) is associated with an increased risk of cancer of the upper gastrointestinal tract. This study aimed to assess whether and to what extent a negative upper endoscopy in patients with GERD is associated with decreased incidence and mortality in upper gastrointestinal cancer (ie, esophageal, gastric, or duodenal cancer).METHODS: We conducted a population-based cohort study of all patients with newly diagnosed GERD between July 1, 1979 and December 31, 2018 in Denmark, Finland, Norway, and Sweden. The exposure, negative upper endoscopy, was examined as a time-varying exposure, where participants contributed unexposed person-time from GERD diagnosis until screened and exposed person-time from the negative upper endoscopy. The incidence and mortality in upper gastrointestinal cancer were assessed using parametric flexible models, providing adjusted hazard ratios (HRs) with 95% confidence intervals (CIs).RESULTS: Among 1,062,740 patients with GERD (median age 58 years; 52% were women) followed for a mean of 7.0 person-years, 5324 (0.5%) developed upper gastrointestinal cancer and 4465 (0.4%) died from such cancer. Patients who had a negative upper endoscopy had a 55% decreased risk of upper gastrointestinal cancer compared with those who did not undergo endoscopy (HR, 0.45; 95% CI, 0.43-0.48), a decrease that was more pronounced during more recent years (HR, 0.34; 95% CI, 0.30-0.38 from 2008 onward), and was otherwise stable across sex and age groups. The corresponding reduction in upper gastrointestinal mortality among patients with upper endoscopy was 61% (adjusted HR, 0.39; 95% CI, 0.37-0.42). The risk reduction after a negative upper endoscopy in incidence and mortality lasted for 5 and at least 10 years, respectively.CONCLUSIONS: Negative upper endoscopy is associated with strong and long-lasting decreases in incidence and mortality in upper gastrointestinal cancer in patients with GERD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Esophageal Neoplasm | |
653 | a Gastric Neoplasm | |
653 | a Gastroesophageal Reflux Disease | |
653 | a Gastroscopy | |
700 | 1 | a Santoni, Giolau Karolinska Institutet4 aut |
700 | 1 | a von Euler-Chelpin, My Catarina4 aut |
700 | 1 | a Färkkilä, Martti4 aut |
700 | 1 | a Kauppila, Joonas Hu Karolinska Institutet4 aut |
700 | 1 | a Maret-Ouda, Johnu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut |
700 | 1 | a Ness-Jensen, Eivindu Karolinska Institutet4 aut |
700 | 1 | a Lagergren, Jesperu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Centrum för klinisk forskning i Sörmland (CKFD)4 org |
773 | 0 | t Gastroenterologyd : Elsevier BVg 162:2, s. 431-438.e4q 162:2<431-438.e4x 0016-5085x 1528-0012 |
856 | 4 | u https://doi.org/10.1053/j.gastro.2021.10.003y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1623133/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.gastrojournal.org/article/S0016508521036179/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462602 |
856 | 4 8 | u https://doi.org/10.1053/j.gastro.2021.10.003 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148667626 |
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