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Effects of a reduce...
Effects of a reduced-sodium added-potassium salt substitute on blood pressure in rural Indian hypertensive patients : a randomized, double-blind, controlled trial.
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Yu, Jie (författare)
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Thout, Sudhir Raj (författare)
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Li, Qiang (författare)
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Tian, Maoyi (författare)
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- Marklund, Matti (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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Arnott, Clare (författare)
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Huffman, Mark D (författare)
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Praveen, Devarsetty (författare)
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Johnson, Claire (författare)
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Huang, Liping (författare)
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Pettigrew, Simone (författare)
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Neal, Bruce (författare)
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Wu, Jason H Y (författare)
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(creator_code:org_t)
- Oxford University Press, 2021
- 2021
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 114:1, s. 185-193
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: High salt intake is a major modifiable risk factor of hypertension which is prevalent in India. It is not yet clear if salt substitutes reduce blood pressure (BP) among Indian hypertensive patients.OBJECTIVES: Examine the acceptability, usage, and BP effects of a reduced-sodium and added-potassium salt substitute among hypertensive patients.METHODS: We enrolled 502 participants with hypertension (aged 61.6 ± 12.0 y, 58.8% women) from 7 villages in rural India. Participants were randomly assigned to receive either regular salt (100% sodium chloride) or the salt substitute (70% sodium chloride/30% potassium chloride blend), and advised to replace all home salt use. The primary outcome was the change in systolic BP (SBP) from baseline to 3 mo comparing the salt substitute and regular salt groups. Secondary outcomes included the change in diastolic BP (DBP), 24-h urinary biomarkers, and self-reported use and satisfaction with the study salt provided.RESULTS: A total of 494 (98%) participants completed 1 mo and 476 (95%) participants completed the 3-mo follow-up. At 3 mo, the salt substitute intervention significantly decreased the average SBP by 4.6 mmHg (95% CI: 3.0, 6.2, P < 0.001) and DBP by 1.1 mmHg (95% CI: 0.2, 2.1 mmHg, P = 0.02). There was a significant increase in 24-h urinary potassium excretion in the salt substitute group by 0.24 g/d (95% CI: 0.12, 0.35 g/d, P < 0.001) and a decrease in the urinary sodium to potassium ratio by 0.71 (95% CI: 0.55, 0.87, P < 0.0001) compared with the control group. Participants reported that they used the study salt nearly every day of the week (mean ± SD, 6.3 ± 1.8 d) and rated the taste of the study salts similarly.CONCLUSION: The reduced-sodium added-potassium salt led to a substantial reduction in SBP in hypertensive patients, supporting salt substitution as an effective, low-cost intervention for BP lowering in rural India. This trial was registered at clinicaltrials.gov as NCT03909659.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- India
- blood pressure
- potassium
- salt substitute
- sodium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Yu, Jie
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Thout, Sudhir Ra ...
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Li, Qiang
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Tian, Maoyi
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Marklund, Matti
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Arnott, Clare
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visa fler...
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Huffman, Mark D
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Praveen, Devarse ...
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Johnson, Claire
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Huang, Liping
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Pettigrew, Simon ...
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Neal, Bruce
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Wu, Jason H Y
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visa färre...
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Uppsala universitet