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Ten-year all-cause ...
Ten-year all-cause death after percutaneous or surgical revascularization in diabetic patients with complex coronary artery disease
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Wang, Rutao (författare)
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Serruys, Patrick W (författare)
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Gao, Chao (författare)
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Hara, Hironori (författare)
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Takahashi, Kuniaki (författare)
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Ono, Masafumi (författare)
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Kawashima, Hideyuki (författare)
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O'leary, Neil (författare)
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Holmes, David R (författare)
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Witkowski, Adam (författare)
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Curzen, Nick (författare)
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Burzotta, Francesco (författare)
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- James, Stefan, 1964- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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van Geuns, Robert-Jan (författare)
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Kappetein, Arie Pieter (författare)
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Morel, Marie-Angele (författare)
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Head, Stuart J (författare)
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Thuijs, Daniel J F M (författare)
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Davierwala, Piroze M (författare)
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O'Brien, Timothy (författare)
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Fuster, Valentin (författare)
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Garg, Scot (författare)
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Onuma, Yoshinobu (författare)
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(creator_code:org_t)
- 2021-08-18
- 2021
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 43:1, s. 56-67
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- AIMS: The aim of this article was to compare rates of all-cause death at 10 years following coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) in patients with or without diabetes.METHODS AND RESULTS: The SYNTAXES study evaluated up to 10-year survival of 1800 patients with three-vessel disease (3VD) and/or left main coronary artery disease (LMCAD) randomized to receive either PCI or CABG in the SYNTAX trial. Ten-year all-cause death according to diabetic status and revascularization strategy was examined. In diabetics (n = 452), the risk of mortality was numerically higher with PCI compared with CABG at 5 years [19.6% vs. 13.3%, hazard ratio (HR): 1.53, 95% confidence interval (CI): 0.96, 2.43, P = 0.075], with the opposite seen between 5 and 10 years (PCI vs. CABG: 20.8% vs. 24.4%, HR: 0.82, 95% CI: 0.52, 1.27, P = 0.366). Irrespective of diabetic status, there was no significant difference in all-cause death at 10 years between patients receiving PCI or CABG, the absolute treatment difference was 1.9% in diabetics (PCI vs. CABG: 36.4% vs. 34.5%, difference: 1.9%, 95% CI: -7.6%, 11.1%, P = 0.551). Among insulin-treated patients (n = 182), all-cause death at 10 years was numerically higher with PCI (47.9% vs. 39.6%, difference: 8.2%, 95% CI: -6.5%, 22.5%, P = 0.227).CONCLUSIONS: The treatment effects of PCI vs. CABG on all-cause death at 10 years in patients with 3VD and/or LMCAD were similar irrespective of the presence of diabetes. There may, however, be a survival benefit with CABG in patients with insulin-treated diabetes. The association between revascularization strategy and very long-term ischaemic and safety outcomes for patients with diabetes needs further investigation in dedicated trials.TRIAL REGISTRATION: SYNTAX: ClinicalTrials.gov reference: NCT00114972 and SYNTAX Extended Survival: ClinicalTrials.gov reference: NCT03417050.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- All-cause death
- Coronary artery bypass grafting
- Diabetes
- Percutaneous coronary intervention
- SYNTAX
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wang, Rutao
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Serruys, Patrick ...
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Gao, Chao
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Hara, Hironori
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Takahashi, Kunia ...
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Ono, Masafumi
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Kawashima, Hidey ...
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O'leary, Neil
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Holmes, David R
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Witkowski, Adam
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Curzen, Nick
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Burzotta, France ...
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James, Stefan, 1 ...
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van Geuns, Rober ...
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Kappetein, Arie ...
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Morel, Marie-Ang ...
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Head, Stuart J
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Thuijs, Daniel J ...
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Davierwala, Piro ...
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O'Brien, Timothy
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Fuster, Valentin
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Garg, Scot
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Onuma, Yoshinobu
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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European Heart J ...
- Av lärosätet
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Uppsala universitet