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IL-22 Downregulates...
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Padhi, AvinashKarolinska Institutet,Karolinska Inst, Dept Med Solna, Dermatol & Venereol Sect, S-17177 Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden.
(författare)
IL-22 Downregulates Peptidylarginine Deiminase-1 in Human Keratinocytes : Adding Another Piece to the IL-22 Puzzle in Epidermal Barrier Formation
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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Elsevier,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-468410
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468410URI
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https://doi.org/10.1016/j.jid.2021.07.155DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148804936URI
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Språk:engelska
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Sammanfattning på:engelska &language:-1_t
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Increased presence of IL-22(+) cells in the skin is a characteristic finding in skin barrier defects, such as psoriasis and atopic dermatitis. However, mechanistic insight into effects of IL-22 on epidermal functioning is yet to be elucidated. One crucial step during epidermal differentiation is deimination or citrullination. Here, we show reduced levels of peptidylarginine deiminase 1, an enzyme that converts peptidylarginine into citrulline in lesional psoriatic skin. IL-22 signaling through the IL-22 receptor complex was found to suppress expression of peptidylarginine deiminase 1 in epidermal keratinocytes. Subsequently, total peptidylarginine deiminase activity and extent of protein deimination in keratinocytes treated with IL-22 were reduced together with a significant decrease in deimination of keratin 1 and FLG, both important for epidermal differentiation. Vitamin D and acitretin partly restored the peptidylarginine deiminase 1 defect caused by IL-22. Collectively, we show that IL-22 downregulates deimination, thus identifying a potential target for treatment of skin barrier defects.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Srivastava, AnkitKarolinska Institutet,Karolinska Inst, Dept Med Solna, Dermatol & Venereol Sect, S-17177 Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.;Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA.
(författare)
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Ramesh, AbarajithaKarolinska Institutet,Uppsala universitet,Mikrobiologi och immunologi
(författare)
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Ehrstrom, MarcusKarolinska Univ Hosp Solna, Dept Reconstruct Plast Surg, Stockholm, Sweden.
(författare)
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Simon, MichelUniv Toulouse, Toulouse Inst Infect & Inflammatory Dis Infin, Ctr Natl Rech Sci CNRS, Inst Natl Sante & Rech Med INSERM,UPS, Toulouse, France.
(författare)
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Sonkoly, EnikoKarolinska Institutet,Karolinska Inst, Dept Med Solna, Dermatol & Venereol Sect, S-17177 Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med CMM, Stockholm, Sweden.;Karolinska Univ Hosp, Unit Dermatol, Stockholm, Sweden.(Swepub:uu)enipi547
(författare)
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Eidsmo, LivKarolinska Institutet,Karolinska Inst, Div Rheumatol, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.;Diagnostiskt Ctr Hud, Stockholm, Sweden.
(författare)
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Bergman, PeterKarolinska Institutet,Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden.
(författare)
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Lysell, JosefinKarolinska Institutet,Karolinska Inst, Dept Med Solna, Dermatol & Venereol Sect, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Unit Dermatol, Stockholm, Sweden.
(författare)
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Karolinska InstitutetKarolinska Inst, Dept Med Solna, Dermatol & Venereol Sect, S-17177 Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Investigative Dermatology: Elsevier142:2, s. 333-342.e60022-202X1523-1747
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