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Sökning: onr:"swepub:oai:DiVA.org:uu-468911" > A prospective multi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006493naa a2200625 4500
001oai:DiVA.org:uu-468911
003SwePub
008220308s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-189869
009oai:DiVA.org:liu-181455
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4689112 URI
0247 a https://doi.org/10.1080/21681805.2021.20024022 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1898692 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1814552 URI
040 a (SwePub)uud (SwePub)umud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Asad, Dannau Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umeå, Sweden.4 aut
2451 0a A prospective multicenter study of visual response-evaluation by cystoscopy in patients undergoing neoadjuvant chemotherapy for muscle invasive urinary bladder cancer
264 c 2021-11-21
264 1b Informa UK Limited,c 2022
338 a electronic2 rdacarrier
500 a Funding Agencies|Swedish Research Council funding for clinical research in medicine (ALF) in Vasterbotten, VLL, Sweden [BasALF/VLL RV-848051]; Cancer Research Foundation in Norrland, Umea, Sweden [CFF LP 13-2000]
520 a Purpose To evaluate a method of transurethral visual response-staging in patients with urothelial muscle-invasive urinary bladder cancer (MIBC), undergoing neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). Methods A prospective study at four Swedish cystectomy centers, cystoscopy was performed after final NAC-cycle for MIBC. Fifty-six participants underwent cystoscopy for visual staging of the tumor immediately pre-RC. Visual assessments were correlated to pathoanatomical outcomes post-RC. Results Seventeen tumors were classified as complete response (CR), i.e. pT0. Twenty-five patients had residual MIBC and 14 had non-muscle invasive residual tumors (NMIBC). Of the 39 patients with residual tumor, 25 were correctly identified visually (64%). Eleven patients were pN+. The diagnostic accuracy of cystoscopy to correctly identify complete response or remaining tumor was 70% (CI = 56-81%) with a sensitivity of 64% (CI = 47-79%), specificity 82% (CI = 57-96%), PPV 89% (CI = 74-96%) and NPV 50% (CI =38-61%). Twenty-eight cystoscopy evaluations showed signs of residual tumors and 3/28 (11%) were false positive. In 4/14 patients assessed having residual NMIBC the estimates were correct, 8/14 had histopathological MIBC and 2/14 had CR. In 11/14 patients (79%), the suggested visual assessment of MIBC was correct, 2/14 had NMIBC and 1/14 had CR. Twenty-eight cystoscopies had negative findings, 14 were false negatives (50%), when cystoscopy falsely predicted pT0. Among them there were eight patients with pTa, pT1 or pTis and six MIBC-tumors. In 17 patients with histopathological pT0, 14 were correctly identified with cystoscopy (82%). Conclusion Cystoscopy after the final NAC-cycle cannot robustly differentiate between NAC-responders and non-responders. Visually, negative MIBC-status cannot be determined safely.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Cystectomy
653 a neoplasm staging
653 a neoadjuvant therapy
653 a urinary bladder neoplasms
7001 a Styrke, Johanu Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umeå, Sweden.4 aut0 (Swepub:umu)jonste00
7001 a Hagsheno, Mohammadu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Univ, Sweden4 aut
7001 a Johansson, Markusu Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umeå, Sweden.4 aut
7001 a Huge, Ylvau Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)ylvhu61
7001 a Svensson, Johan,d 1978-u Umeå universitet,Statistik,Umeå Univ, Umeå Sch Business Econ & Stat USBE, Dept Stat, Umeå, Sweden.4 aut0 (Swepub:umu)josv0027
7001 a Pelander, Sofiau Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)n/a
7001 a Lauer, Janu Nyköping Cty Hosp, Dept Surg, Nyköping, Sweden.4 aut
7001 a Netterling, Hansu Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umeå, Sweden.4 aut0 (Swepub:umu)halu0001
7001 a Abdul-Sattar Aljabery, Firasu Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)firab05
7001 a Sherif, Amiru Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umeå, Sweden.4 aut0 (Swepub:umu)amsh0008
7102 a Umeå universitetb Urologi och andrologi4 org
7730 t Scandinavian journal of urologyd : Informa UK Limitedg 56:1, s. 20-26q 56:1<20-26x 2168-1805x 2168-1813
8564 u https://doi.org/10.1080/21681805.2021.2002402y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1643034/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.tandfonline.com/doi/pdf/10.1080/21681805.2021.2002402?needAccess=true
8564 u https://umu.diva-portal.org/smash/get/diva2:1613870/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://liu.diva-portal.org/smash/get/diva2:1615468/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468911
8564 8u https://doi.org/10.1080/21681805.2021.2002402
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189869
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-181455

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