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Sökning: onr:"swepub:oai:DiVA.org:uu-469028" > Identification of 3...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005957naa a2200553 4500
001oai:DiVA.org:uu-469028
003SwePub
008220304s2021 | |||||||||||000 ||eng|
009oai:hhs.se:1162102330006056
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4690282 URI
0247 a https://doi.org/10.1038/s41562-021-01135-32 DOI
0247 a https://research.hhs.se/esploro/outputs/journalArticle/Identification-of-371-genetic-variants-for/9910015254995060562 URI
040 a (SwePub)uud (SwePub)hhs
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mills, Melinda C.u Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.,University of Oxford4 aut
2451 0a Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
264 c 2021-07-01
264 1b Springer Nature,c 2021
338 a print2 rdacarrier
500 a These authors contributed equally: Melinda C. Mills, Felix C. Tropf, David M. Brazel, Marcel den Hoed, Nicola Barban, Felix R. Day
520 a Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility. This genome-wide study of age at first sexual intercourse and first birth identifies 371 signals driven by reproductive biology, externalising behaviour and environmental effects, with later onset associated with lower incidence of some diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
7001 a Tropf, Felix C.u Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.;Ecole Natl Stat & Adm Econ ENSAE, Paris, France.;Ctr Res Econ & Stat CREST, Paris, France.,University of Oxford4 aut
7001 a Brazel, David M.u Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.,University of Oxford4 aut
7001 a van Zuydam, Natalieu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi4 aut
7001 a Vaez, Ahmadu Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Isfahan Univ Med Sci, Dept Bioinformat, Esfahan, Iran.,University Medical Center Groningen4 aut
7001 a Pers, Tune H.u Univ Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.,Statens Serum Institut4 aut
7001 a Snieder, Haroldu Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.,University Medical Center Groningen4 aut
7001 a Perry, John R. B.u Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge4 aut
7001 a Ong, Ken K.u Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge4 aut
7001 a den Hoed, Marcel,d 1980-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Uppsala University4 aut0 (Swepub:uu)marde358
7001 a Barban, Nicolau Univ Bologna, Dept Stat Sci, Bologna, Italy.,University of Bologna4 aut
7001 a Day, Felix R.u Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge4 aut
7001 a Johannesson, Magnusu Stockholm School of Economics,Handelshögskolan i Stockholm4 aut0 (Swepub:hhs)198@hhs.se
7102 a Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.b University of Oxford4 org
7102 a Human Reproductive Behaviour Consortium
7730 t Nature Human Behaviourd : Springer Natureg 5:12, s. 1717-1730q 5:12<1717-1730x 2397-3374
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612120
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469028
8564 8u https://doi.org/10.1038/s41562-021-01135-3
8564 8u https://research.hhs.se/esploro/outputs/journalArticle/Identification-of-371-genetic-variants-for/991001525499506056

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