Sökning: onr:"swepub:oai:DiVA.org:uu-469184" > In Vitro Anticancer...
Fältnamn | Indikatorer | Metadata |
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000 | 04764naa a2200565 4500 | |
001 | oai:DiVA.org:uu-469184 | |
003 | SwePub | |
008 | 220307s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4691842 URI |
024 | 7 | a https://doi.org/10.3390/biomedicines100100412 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Burgos-Moron, Estefaniau Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut |
245 | 1 0 | a In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside |
264 | c 2021-12-25 | |
264 | 1 | b MDPI AG,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a We recently screened a series of new aziridines beta-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-beta-D-galactopyranoside (AzGalp) as the most promising compound. In this article, we explore the possible mechanisms involved in the cytotoxicity of this aziridine and evaluate its selective anticancer activity using cancer cells and normal cells from a variety of tissues. Our data show that AzGalp induces DNA damage (comet assay). Cells deficient in the nucleotide excision repair (NER) pathway were hypersensitive to the cytotoxicity of this compound. These results suggest that AzGalp induces bulky DNA adducts, and that cancer cells lacking a functional NER pathway may be particularly vulnerable to the anticancer effects of this aziridine. Several experiments revealed that neither the generation of oxidative stress nor the inhibition of glycolysis played a significant role in the cytotoxicity of AzGalp. Combinations of AzGalp with oxaliplatin or 5-fluorouracil slightly improved the ability of both anticancer drugs to selectively kill cancer cells. AzGalp also showed selective cytotoxicity against a panel of malignant cells versus normal cells; the highest selectivity was observed for two acute promyelocytic leukemia cell lines. Additional preclinical studies are necessary to evaluate the anticancer potential of AzGalp. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Nanoteknik0 (SwePub)2102 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Nano-technology0 (SwePub)2102 hsv//eng |
653 | a aziridine | |
653 | a cancer | |
653 | a cytotoxic | |
653 | a cytotoxicity | |
653 | a selectivity | |
653 | a nucleotide excision repair | |
653 | a Engineering Science with specialization in Nanotechnology and Functional Materials | |
653 | a Teknisk fysik med inriktning mot nanoteknologi och funktionella material | |
700 | 1 | a Pastor, Nuriau Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 aut |
700 | 1 | a Orta, Manuel Luisu Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 aut |
700 | 1 | a Jimenez-Alonso, Julio Joseu Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut |
700 | 1 | a Palo-Nieto, Carlosu Uppsala universitet,Nanoteknologi och funktionella material,Institutionen för läkemedelskemi,Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut0 (Swepub:uu)carpa373 |
700 | 1 | a Vega-Holm, Margaritau Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut |
700 | 1 | a Vega-Perez, Jose Manuelu Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut |
700 | 1 | a Iglesias-Guerra, Fernandou Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut |
700 | 1 | a Mateos, Santiagou Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 aut |
700 | 1 | a Lopez-Lazaro, Miguelu Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut |
700 | 1 | a Calderon-Montano, Jose Manuelu Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut |
710 | 2 | a Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.b Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 org |
773 | 0 | t Biomedicinesd : MDPI AGg 10:1q 10:1x 2227-9059 |
856 | 4 | u https://doi.org/10.3390/biomedicines10010041y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1642716/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.mdpi.com/2227-9059/10/1/41/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469184 |
856 | 4 8 | u https://doi.org/10.3390/biomedicines10010041 |
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