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Spatial Immunology ...
Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern
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- Garcia-Vicien, Gemma (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.
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- Mezheyeuski, Artur (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Micke, Patrick (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Ruiz, Nuria (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.;Hosp Univ Bellvitge, Dept Pathol, Barcelona 08908, Catalonia, Spain.
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- Ruffinelli, Jose Carlos (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.;Inst Catala Oncol, Dept Med Oncol, Barcelona 08908, Catalonia, Spain.
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- Mils, Kristel (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.;Hosp Univ Bellvitge, Dept Surg, Barcelona 08908, Catalonia, Spain.
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- Banuls, Maria (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.
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- Molina, Natalia (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.
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- Losa, Ferran (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.;Inst Catala Oncol, Dept Med Oncol, Barcelona 08908, Catalonia, Spain.
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- Llado, Laura (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.;Hosp Univ Bellvitge, Dept Surg, Barcelona 08908, Catalonia, Spain.
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- Mollevi, David G. (författare)
- Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain.;Inst Catala Oncol, Program Canc Therapeut Resistance ProCURE, Barcelona 08908, Catalonia, Spain.
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Inst Invest Biomed Bellvitge IDIBELL, Tumoral & Stromal Chemoresistance Grp, Oncobell Program, Gran Via 197-203, Barcelona 08908, Catalonia, Spain Experimentell och klinisk onkologi (creator_code:org_t)
- 2022-01-29
- 2022
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:3
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Simple Summary In the era of immunotherapy, the tumor microenvironment (TME) has attracted special interest. However, colorectal liver metastases (CRC-LM) present histological peculiarities that could affect the interaction of immune and tumor cells such as fibrotic encapsulation and dense intratumoral stroma. We explored the spatial distribution of lymphocytic infiltrates in CRC-LM in the context of the histologic growth patterns using multispectral digital pathology providing data on three different scenarios, tumor periphery, invasive margin, and central tumoral areas. Our results illustrate a similar poor cell density of CD8(+) cells between different metastases subtypes in intratumoral regions. However, in encapsulated metastases, cytotoxic cells reach the tumor cells while remaining retained in stromal areas in non-encapsulating metastases. Some aspects are still unresolved, such as understanding the reason why most lymphocytes are largely retained in the capsule. Colorectal cancer liver metastases (CRC-LM) present differential histologic growth patterns (HGP) that determine the interaction between immune and tumor cells. We explored the spatial distribution of lymphocytic infiltrates in CRC-LM in the context of the HGP using multispectral digital pathology. We did not find statistically significant differences of immune cell densities in the central regions of desmoplastic ((d)HGP) and non-desmoplastic ((nd)HGP) metastases. The spatial evaluation reported that (d)HGP-metastases displayed higher infiltration by CD8(+) and CD20(+) cells in peripheral regions as well as CD4(+) and CD45RO(+) cells in (nd)HGP-metastases. However, the reactive stroma regions at the invasive margin (IM) of (nd)HGP-metastases displayed higher density of CD4(+), CD20(+), and CD45RO(+) cells. The antitumor status of the TIL infiltrates measured as CD8/CD4 reported higher values in the IM of encapsulated metastases up to 400 mu m towards the tumor center (p < 0.05). Remarkably, the IM of (d)HGP-metastases was characterized by higher infiltration of CD8(+) cells in the epithelial compartment parameter assessed with the ratio CD8(epithelial)/CD8(stromal), suggesting anti-tumoral activity in the encapsulating lesions. Taking together, the amount of CD8(+) cells is comparable in the IM of both HGP metastases types. However, in (d)HGP-metastases some cytotoxic cells reach the tumor nests while remaining retained in the stromal areas in (nd)HGP-metastases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- liver metastases
- lymphocyte
- immunology
- desmoplasia
- growth pattern
- multiplex
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cancers
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Garcia-Vicien, G ...
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Mezheyeuski, Art ...
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Micke, Patrick
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Ruiz, Nuria
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Ruffinelli, Jose ...
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Mils, Kristel
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Banuls, Maria
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Molina, Natalia
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Losa, Ferran
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Llado, Laura
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Mollevi, David G ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Cancers
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Uppsala universitet