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Pharmacometrics mee...
Pharmacometrics meets statistics-A synergy for modern drug development
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- Ryeznik, Yevgen (författare)
- AstraZeneca, R&D Biopharmaceut, Data Sci & AI, BioPharma Early Biometr & Stat Innovat, Gothenburg, Sweden.
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- Sverdlov, Oleksandr (författare)
- Novartis Pharmaceut, Early Dev Analyt, E Hanover, NJ USA.
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- Svensson, Elin, 1985- (författare)
- Uppsala universitet,Institutionen för farmaci,Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Pharm, Nijmegen, Netherlands.
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- Montepiedra, Grace (författare)
- Harvard TH Chan Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA USA.
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- Hooker, Andrew, 1973- (författare)
- Uppsala universitet,Institutionen för farmaci
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- Wong, Weng Kee (författare)
- Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA.
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AstraZeneca, R&D Biopharmaceut, Data Sci & AI, BioPharma Early Biometr & Stat Innovat, Gothenburg, Sweden Novartis Pharmaceut, Early Dev Analyt, E Hanover, NJ USA. (creator_code:org_t)
- 2021-08-19
- 2021
- Engelska.
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Ingår i: CPT. - : John Wiley & Sons. - 2163-8306. ; 10:10, s. 1134-1149
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Modern drug development problems are very complex and require integration of various scientific fields. Traditionally, statistical methods have been the primary tool for design and analysis of clinical trials. Increasingly, pharmacometric approaches using physiology-based drug and disease models are applied in this context. In this paper, we show that statistics and pharmacometrics have more in common than what keeps them apart, and collectively, the synergy from these two quantitative disciplines can provide greater advances in clinical research and development, resulting in novel and more effective medicines to patients with medical need.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Collaboration
- integration of fields
- model-based adaptive optimal designs
- model-informed drug development
- problem solving
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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