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Expression of PD-1,...
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Hellbacher, ErikUppsala universitet,Reumatologi
(författare)
Expression of PD-1, PD-L1 and PD-L2 in Lymphomas in Patients with Pre-Existing Rheumatic Diseases-A Possible Association with High Rheumatoid Arthritis Disease Activity
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-03-15
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MDPI,2022
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-472740
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-472740URI
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https://doi.org/10.3390/cancers14061509DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Simple Summary Immunotherapy blocking programmed cell death protein 1 (PD-1) and its ligands (PD-L1, PD-L2) is less effective in non-Hodgkin lymphoma (NHL) than classical Hodgkin lymphoma. However, NHL is a heterogeneous group and current research seeks to identify subgroups of NHL patients responsive to PD-1 blocking agents. Whether patients with pre-existing rheumatic diseases might constitute such a subgroup is unknown. We investigated the expression of PD-1 and its ligands in lymphoma patients with pre-existing rheumatic diseases. Our key findings include that in patients with pre-existing rheumatoid arthritis (RA) and subsequent diffuse large B-cell lymphoma, an association between RA disease severity and increased expression of PD-L1 in tumor cells was seen. This warrants further studies of the PD-1 pathway in lymphoma in other chronic inflammatory conditions. Current research seeks to identify subgroups of non-Hodgkin lymphoma (NHL) patients responsive to PD-1 blocking agents. Whether patients with pre-existing rheumatic diseases might constitute such a subgroup is unknown. We determined intratumoral expression of PD-1 and its ligands in lymphoma patients with pre-existing rheumatic diseases. We included 215 patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or Sjogren's syndrome with subsequent lymphoma and 74 diffuse large B-cell lymphoma (DLBCL) controls without rheumatic disease. PD-1 and PD-ligand immunohistochemical markers were applied on tumor tissue microarrays. The number of PD-1+ tumor infiltrating leukocytes (TILs) and proportions of PD-L1+ and PD-L2+ tumor cells and TILs were calculated and correlated with clinical data. Expression of PD-L1 in tumor cells and TILs was highest in classical Hodgkin lymphoma and DLBCL. In DLBCLs, expression of PD-1 in TILs and PD-L1 in tumor cells was similar in RA, SLE and controls. In RA-DLBCL, high expression of PD-L1 in tumor cells was significantly more common in patients with the most severe RA disease and was associated with inferior overall survival in multivariable analysis.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sundström, ChristerUppsala universitet,Experimentell och klinisk onkologi,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)chrisund
(författare)
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Molin, Daniel,1969-Uppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)danimoli
(författare)
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Baecklund, Eva,1956-Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)evaba786
(författare)
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Hollander, PeterUppsala universitet,Experimentell och klinisk onkologi,Klinisk och experimentell patologi(Swepub:uu)petho189
(författare)
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Uppsala universitetReumatologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancers: MDPI14:62072-6694
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