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Time to castration-...
Time to castration-resistant prostate cancer and prostate cancer death according to PSA response in men with non-metastatic prostate cancer treated with gonadotropin releasing hormone agonists
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- Bonde, Tiago M. (författare)
- Department of Urology, Ryhov Hospital, Jönköping, Sweden
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- Westerberg, Marcus, 1990- (författare)
- Uppsala universitet,Statistik, AI och data science
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- Aly, Markus (författare)
- Karolinska Institutet
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- Eklund, Martin (författare)
- Karolinska Institutet
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- Adolfsson, Jan (författare)
- Karolinska Institutet
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- Bill-Axelson, Anna (författare)
- Uppsala universitet,Urologkirurgi
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- Garmo, Hans (författare)
- Uppsala universitet,Urologkirurgi
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- Stattin, Pär (författare)
- Uppsala universitet,Urologkirurgi
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- Robinson, David (författare)
- Department of Urology, Ryhov Hospital, Jönköping, Sweden
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(creator_code:org_t)
- 2022-05-12
- 2022
- Engelska.
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Ingår i: Scandinavian journal of urology. - : Taylor & Francis Group. - 2168-1805 .- 2168-1813. ; 56:3, s. 169-175
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: To predict castration-resistant prostate cancer (CRPC) and prostate cancer (Pca) death by use of clinical variables at Pca diagnosis and PSA levels after start of gonadotropin-releasing hormone agonists (GnRH) in men with non-metastatic castration sensitive prostate cancer (nmCSPC).Materials and Methods: PSA values for 1603 men with nmCSPC in the National Prostate Cancer Register of Sweden who received GnRH as primary treatment were retrieved from Uppsala-Örebro PSA Cohort and Stockholm PSA and Biopsy Register. All men had measured PSA before (pre-GnRH PSA) and 3–6 months after (post-GnRH PSA) date of start of GnRH. Unadjusted and adjusted Cox models were used to predict CRPC by PSA levels. PSA levels and ISUP grade were used to construct a risk score to stratify men by tertiles according to risk of CRPC and Pca death.Results: 788 (49%) men reached CRPC and 456 (28%) died of Pca during follow-up. Post-GnRH PSA predicted CRPC regardless of pre-GnRH PSA. CRPC risk increased with higher post-GnRH PSA, HR 4.7 (95% CI: 3.4–6.7) for PSA > 16 ng/mL vs 0–0.25 ng/mL and with ISUP grade, HR 3.7 (95%: 2.5–5.4) for ISUP 5 vs ISUP 1. Risk of Pca death in men above top vs bellow bottom tertile of post-GnRH PSA and ISUP grade was HR 4.1 (95% CI: 3.0–5.5).Conclusion: A risk score based on post-GnRH PSA and ISUP grade could be used for early identification of a target group for future clinical trials on additional therapy to GnRH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- prostatic neoplasms
- castration-resistant
- neoplasm grading
- prostate-specific antigen
- gonadotropin-releasing hormone
- prognosis
- mortality
- Urologi
- Urology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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