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Time to castration-...
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Bonde, Tiago M.Department of Urology, Ryhov Hospital, Jönköping, Sweden
(författare)
Time to castration-resistant prostate cancer and prostate cancer death according to PSA response in men with non-metastatic prostate cancer treated with gonadotropin releasing hormone agonists
- Artikel/kapitelEngelska2022
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2022-05-12
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Taylor & Francis Group,2022
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-474430
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-474430URI
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https://doi.org/10.1080/21681805.2022.2070275DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149596225URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Objectives: To predict castration-resistant prostate cancer (CRPC) and prostate cancer (Pca) death by use of clinical variables at Pca diagnosis and PSA levels after start of gonadotropin-releasing hormone agonists (GnRH) in men with non-metastatic castration sensitive prostate cancer (nmCSPC).Materials and Methods: PSA values for 1603 men with nmCSPC in the National Prostate Cancer Register of Sweden who received GnRH as primary treatment were retrieved from Uppsala-Örebro PSA Cohort and Stockholm PSA and Biopsy Register. All men had measured PSA before (pre-GnRH PSA) and 3–6 months after (post-GnRH PSA) date of start of GnRH. Unadjusted and adjusted Cox models were used to predict CRPC by PSA levels. PSA levels and ISUP grade were used to construct a risk score to stratify men by tertiles according to risk of CRPC and Pca death.Results: 788 (49%) men reached CRPC and 456 (28%) died of Pca during follow-up. Post-GnRH PSA predicted CRPC regardless of pre-GnRH PSA. CRPC risk increased with higher post-GnRH PSA, HR 4.7 (95% CI: 3.4–6.7) for PSA > 16 ng/mL vs 0–0.25 ng/mL and with ISUP grade, HR 3.7 (95%: 2.5–5.4) for ISUP 5 vs ISUP 1. Risk of Pca death in men above top vs bellow bottom tertile of post-GnRH PSA and ISUP grade was HR 4.1 (95% CI: 3.0–5.5).Conclusion: A risk score based on post-GnRH PSA and ISUP grade could be used for early identification of a target group for future clinical trials on additional therapy to GnRH.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Westerberg, Marcus,1990-Uppsala universitet,Statistik, AI och data science(Swepub:uu)marwe776
(författare)
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Aly, MarkusKarolinska Institutet
(författare)
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Eklund, MartinKarolinska Institutet
(författare)
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Adolfsson, JanKarolinska Institutet
(författare)
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Bill-Axelson, AnnaUppsala universitet,Urologkirurgi(Swepub:uu)anbil030
(författare)
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Garmo, HansUppsala universitet,Urologkirurgi(Swepub:uu)hga27600
(författare)
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Stattin, PärUppsala universitet,Urologkirurgi(Swepub:uu)parst892
(författare)
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Robinson, DavidDepartment of Urology, Ryhov Hospital, Jönköping, Sweden
(författare)
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Department of Urology, Ryhov Hospital, Jönköping, SwedenStatistik, AI och data science
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian journal of urology: Taylor & Francis Group56:3, s. 169-1752168-18052168-1813
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