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Spatial-Temporal Pa...
Spatial-Temporal Patterns of beta-Amyloid Accumulation A Subtype and Stage Inference Model Analysis
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- Collij, Lyduine E. (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- Salvado, Gemma (författare)
- Pasqual Maragall Fdn, Barcelona Eta Brain Res Ctr BBRC, Barcelona, Spain.;IMIM Hosp del Mar Med Res Inst, Barcelona, Spain.
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- Wottschel, Viktor (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- Mastenbroek, Sophie E. (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- Schoenmakers, Pierre (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam UMC, Dept Neurol, Amsterdam, Netherlands.
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- Heeman, Fiona (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- Aksman, Leon (författare)
- Univ Southern Calif, Stevens Neuroimaging & Informat Inst, Keck Sch Med, Los Angeles, CA 90007 USA.
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- Wink, Alle Meije (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- Berckel, Bart N. M. (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- van de Flier, Wiesje M. (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Alzheimer Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam UMC, Dept Neurol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam, Netherlands.
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- Scheltens, Philip (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Alzheimer Ctr, Amsterdam, Netherlands.
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- Visser, Pieter Jelle (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Alzheimer Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam UMC, Dept Neurol, Amsterdam, Netherlands.
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- Barkhof, Frederik (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.;UCL, Ctr Med Image Comp, London, England.;UCL, Queen Sq Inst Neurol, London, England.
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- Haller, Sven (författare)
- Uppsala universitet,Radiologi,Univ Geneva, Fac Med, Geneva, Switzerland.;CIMC Ctr Imagerie Med Cornavin, Geneva, Switzerland.;Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China.
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- Domingo Gispert, Juan (författare)
- Pasqual Maragall Fdn, Barcelona Eta Brain Res Ctr BBRC, Barcelona, Spain.;IMIM Hosp del Mar Med Res Inst, Barcelona, Spain.;Ctr Invest Biomed Red Bioingn Biomat & Nanomed CI, Madrid, Spain.
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- Alves, Isadora Lopes (författare)
- Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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Vrije Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands Pasqual Maragall Fdn, Barcelona Eta Brain Res Ctr BBRC, Barcelona, Spain.;IMIM Hosp del Mar Med Res Inst, Barcelona, Spain. (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- Engelska.
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Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 98:17, s. E1692-E1703
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Objectives beta-amyloid (A beta) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for A beta accumulation subtypes by applying the data-driven Subtype and Stage Inference (SuStaIn) model to amyloid-PET data. Methods Amyloid-PET data of 3,010 participants were pooled from 6 cohorts (ALFA+, EMIF-AD, ABIDE, OASIS, and ADNI). Standardized uptake value ratios were calculated for 17 regions. We applied the SuStaIn algorithm to identify consistent subtypes in the pooled dataset based on the cross-validation information criterion and the most probable subtype/stage classification per scan. The effects of demographics and risk factors on subtype assignment were assessed using multinomial logistic regression. Results Participants were mostly cognitively unimpaired (n = 1890 [62.8%]), had a mean age of 68.72 (SD 9.1) years, 42.1% were APOE epsilon 4 carriers, and 51.8% were female. A 1-subtype model recovered the traditional amyloid accumulation trajectory, but SuStaIn identified 3 optimal subtypes, referred to as frontal, parietal, and occipital based on the first regions to show abnormality. Of the 788 (26.2%) with strong subtype assignment (>50% probability), the majority was assigned to frontal (n = 415 [52.5%]), followed by parietal (n = 199 [25.3%]) and occipital subtypes (n = 175 [22.2%]). Significant differences across subtypes included distinct proportions of APOE epsilon 4 carriers (frontal 61.8%, parietal 57.1%, occipital 49.4%), participants with dementia (frontal 19.7%, parietal 19.1%, occipital 31.0%), and lower age for the parietal subtype (frontal/occipital 72.1 years, parietal 69.3 years). Higher amyloid (Centiloid) and CSF p-tau burden was observed for the frontal subtype; parietal and occipital subtypes did not differ. At follow-up, most participants (81.1%) maintained baseline subtype assignment and 25.6% progressed to a later stage. Discussion Whereas a 1-trajectory model recovers the established pattern of amyloid accumulation, SuStaIn determined that 3 subtypes were optimal, showing distinct associations with Alzheimer disease risk factors. Further analyses to determine clinical utility are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Collij, Lyduine ...
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Salvado, Gemma
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Wottschel, Vikto ...
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Mastenbroek, Sop ...
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Schoenmakers, Pi ...
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Heeman, Fiona
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Aksman, Leon
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Wink, Alle Meije
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Berckel, Bart N. ...
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van de Flier, Wi ...
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Scheltens, Phili ...
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Visser, Pieter J ...
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Barkhof, Frederi ...
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Haller, Sven
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Domingo Gispert, ...
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Alves, Isadora L ...
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Neurology
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Uppsala universitet