Long-term outcomes of ablation, liver resection, and liver transplant as first-line treatment for solitary HCC of 3 cm or less using an intention-to-treat analysis: A retrospective cohort study

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Long-term outcomes of ablation, liver resection, and liver transplant as first-line treatment for solitary HCC of 3 cm or less using an intention-to-treat analysis : A retrospective cohort study

Ivanics, Tommy (författare): Uppsala universitet,Gastrointestinalkirurgi,Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.;Henry Ford Hosp, Dept Surg, Detroit, MI 48202 USA.

Rajendran, L. (författare): Univ Toronto, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Abreu, P. A. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

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Claasen, M. P. A. W. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.;Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.

Shwaartz, C. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.;Univ Toronto, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Patel, M. S. (författare): Univ Texas Southwestern Med Ctr Dallas, Dept Surg, Div Surg Transplantat, Dallas, TX USA.

Choi, W. J. (författare): Univ Toronto, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Doyle, A. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Muaddi, H. (författare): Univ Toronto, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

McGilvray, I. D. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.;Univ Toronto, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Selzner, M. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Beecroft, R. (författare): Univ Toronto, Mt Sinai Hosp & Univ Hlth Network, Joint Dept Med Imaging, Toronto, ON, Canada.

Kachura, J. (författare): Univ Toronto, Toronto Gen Hosp, Dept Radiol, Toronto, ON, Canada.

Bhat, M. (författare): Univ Hlth Network, Toronto Gen Hosp Res Inst, Multiorgan Transplant Program, Toronto, ON, Canada.;Univ Toronto, Dept Med, Div Gastroenterol, Toronto, ON, Canada.

Selzner, N. (författare): Univ Hlth Network, Toronto Gen Hosp Res Inst, Multiorgan Transplant Program, Toronto, ON, Canada.

Ghanekar, A. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Cattral, M. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Sayed, B. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Reichman, T. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

Lilly, L. (författare): Univ Hlth Network, Toronto Gen Hosp Res Inst, Multiorgan Transplant Program, Toronto, ON, Canada.

Sapisochin, G. (författare): Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.;Univ Toronto, Toronto Gen Hosp, Div Gen Surg, Toronto, ON, Canada.

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Elsevier, 2022
2022
Engelska.
Ingår i: Annals of Medicine and Surgery. - : Elsevier. - 2049-0801. ; 77

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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Background: Curative-intent therapies for hepatocellular carcinoma (HCC) include radiofrequency ablation (RFA), liver resection (LR), and liver transplantation (LT). Controversy exists in treatment selection for earlystage tumours. We sought to evaluate the oncologic outcomes of patients who received either RFA, LR, or LT as first-line treatment for solitary HCC < 3 cm in an intention-to-treat analysis.Materials and methods: All patients with solitary HCC < 3 cm who underwent RFA, LR, or were listed for LT between Feb-2000 and Nov-2018 were analyzed. Cox regression analysis was then performed to compare intention-to-treat (ITT) survival by initial treatment allocation and disease-free survival (DFS) by treatment received in patients eligible for all three treatments.Results: A total of 119 patients were identified (RFA n = 83; LR n = 25; LT n = 11). The overall intention-to-treat survival was similar between the three groups. The overall DFS was highest for the LT group. This was significantly higher than RFA (p = 0.02), but not statistically significantly different from LR (p = 0.14). After multivariable adjustment, ITT survival was similar in the LR and LT groups relative to RFA (LR HR:1.13, 95%CI 0.33-3.82; p = 0.80; LT HR:1.39, 95%CI 0.35-5.44; p = 0.60). On multivariable DFS analysis, only LT was better relative to RFA (LR HR:0.52, 95%CI 0.26-1.02; p = 0.06; LT HR:0.15, 95%CI 0.03-0.67; p = 0.01). Compared to LR, LT was associated with a numerically lower hazard on multivariable DFS analysis, though this did not reach statistical significance (HR 0.30, 95%CI 0.06-1.43; p = 0.13)Conclusion: For treatment-naive patients with solitary HCC < 3 cm who are eligible for RFA, LR, and LT, adjusted ITT survival is equivalent amongst the treatment modalities, however, DFS is better with LR and LT, compared with RFA. Differences in recurrence between treatment modalities and equipoise in ITT survival provides support for a future prospective trial in this setting.

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Av författaren/redakt...: Ivanics, Tommy; Rajendran, L.; Abreu, P. A.; Claasen, M. P. A ...; Shwaartz, C.; Patel, M. S.; visa fler...; Choi, W. J.; Doyle, A.; Muaddi, H.; McGilvray, I. D.; Selzner, M.; Beecroft, R.; Kachura, J.; Bhat, M.; Selzner, N.; Ghanekar, A.; Cattral, M.; Sayed, B.; Reichman, T.; Lilly, L.; Sapisochin, G.; visa färre...

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Long-term outcomes of ablation, liver resection, and liver transplant as first-line treatment for solitary HCC of 3 cm or less using an intention-to-treat analysis : A retrospective cohort study

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