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Mitigation of DSS-I...
Mitigation of DSS-Induced Colitis Potentially via Th1/Th2 Cytokine and Immunological Function Balance Induced by Phenolic-Enriched Buckwheat (Fagopyrum esculentum Moench) Bee Pollen Extract
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- Chen, Sinan (författare)
- Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.
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- Xu, Yifei (författare)
- Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.
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- Cheng, Ni (författare)
- Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.;Bee Prod Res Ctr Shaanxi Prov, Xian 710065, Peoples R China.
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- Li, Feng (författare)
- Northwest Univ, Sch Chem Engn, Xian 710069, Peoples R China.
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- Zhao, Haoan (författare)
- Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.
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- Bai, Naisheng (författare)
- Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.,Farmakognosi
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- Cao, Wei (författare)
- Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.;Bee Prod Res Ctr Shaanxi Prov, Xian 710065, Peoples R China.
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Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.;Bee Prod Res Ctr Shaanxi Prov, Xian 710065, Peoples R China. (creator_code:org_t)
- 2022-04-29
- 2022
- Engelska.
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Ingår i: Foods. - : MDPI AG. - 2304-8158. ; 11:9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Colitis is an inflammatory disease that results from the overactivation of effector immune cells, producing a high quantity of pro-inflammatory cytokines. Our study aimed to explore whether buckwheat (F. esculentum) bee pollen extract (FBPE) could inhibit the progression of dextran sulfate sodium (DSS)-induced colitis via regulating immune function. We isolated and identified six main phenolic compounds of FBPE such as luteolin (9.46 mg/g) by column chromatography, HPLC-DAD, ESI-MS and NMR spectroscopy, then assessed their effects on colonic mucosal injury by clinical symptoms, histomorphology and immunohistochemistry examinations. The results showed that FBPE at 25.2 g/kg body weight (g/kg BW) changed the clinical symptoms of colitis, the ICAM-1 expression in colon, the activity of related inflammatory mediators in colon tissue and helped restore the immune system. Compared with the model group (40.28%), the CD4 positivity was significantly reduced in the HD (High-dose group: 25.2 g FBPE/kg BW/day) group (20.45%). Administration of 25.2 g/kg BW of FBPE decreased the IFN-gamma, TNF-alpha and IL-4 levels, while enhancing the IL-10 level, and significantly inhibited the abnormally decreased IgG (Model: 13.25 mg/mL, HD: 14.06 mg/mL), showing a reversal effect on the Th1/Th2 levels in colitis. These findings suggested that FBPE at 25.2 g/kg BW had the effects of alleviating colitis and immunomodulation, which can help in the development of safe and effective immune therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- colitis
- immunity
- Th1/Th2
- buckwheat bee pollen
- phenolic compounds
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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