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Spectral Ultrasound Imaging of Speed-of-Sound and Attenuation Using an Acoustic Mirror
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- Chintada, Bhaskara Rao (författare)
- Swiss Fed Inst Technol, Comp Assisted Applicat Med, Zurich, Switzerland.
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- Rau, Richard (författare)
- Swiss Fed Inst Technol, Comp Assisted Applicat Med, Zurich, Switzerland.
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- Göksel, Orcun (författare)
- Uppsala universitet,Avdelningen Vi3,Bildanalys och människa-datorinteraktion,Swiss Fed Inst Technol, Comp Assisted Applicat Med, Zurich, Switzerland.
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Swiss Fed Inst Technol, Comp Assisted Applicat Med, Zurich, Switzerland Avdelningen Vi3 (creator_code:org_t)
- 2022-05-11
- Engelska.
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Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 10
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Ämnesord
Stäng
- Speed-of-sound and attenuation of ultrasound waves vary in the tissues. There exist methods in the literature that allow for spatially reconstructing the distribution of group speed-of-sound (SoS) and frequency-dependent ultrasound attenuation (UA) using reflections from an acoustic mirror positioned at a known distance from the transducer. These methods utilize a conventional ultrasound transducer operating in pulse-echo mode and a calibration protocol with measurements in water. In this study, we introduce a novel method for reconstructing local SoS and UA maps as a function of acoustic frequency through Fourier-domain analysis and by fitting linear and power-law dependency models in closed form. Frequency-dependent SoS and UA together characterize the tissue comprehensively in spectral domain within the utilized transducer bandwidth. In simulations, our proposed methods are shown to yield low reconstruction error: 0.01 dB/cm.MHz(y) for attenuation coefficient and 0.05 for the frequency exponent. For tissue-mimicking phantoms and ex-vivo bovine muscle samples, a high reconstruction contrast was achieved. Attenuation exponents in a gelatin-cellulose mixture and an ex-vivo bovine muscle sample were found to be, respectively, 1.3 and 0.6 on average. Linear dispersion of SoS in a gelatin-cellulose mixture and an ex-vivo bovine muscle sample were found to be, respectively, 1.3 and 4.0 m/s.MHz on average. These findings were reproducible when the inclusion and substrate materials were exchanged. Bulk loss modulus in the bovine muscle sample was computed to be approximately 4 times the bulk loss modulus in the gelatin-cellulose mixture. Such frequency-dependent characteristics of SoS and UA, and bulk loss modulus may therefore differentiate tissues as potential diagnostic biomarkers.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Nyckelord
- ultrasound tomography
- ultrasound attenuation
- viscoelasticity
- complex bulk modulus
- speed of sound
- Computerized Image Processing
- Datoriserad bildbehandling
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)