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COVID-19 seropreval...
COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients
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- Sundberg, Emil, 1990- (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning,Department of Children's Oncology and Hematology Uppsala University Hospital Uppsala Sweden
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- Hoffman, Tove (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Nilsson, Anna (författare)
- Karolinska Institutet
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- Pahnke, Simon (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Enblad, Gunilla (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Kolstad, Linda (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Rönnberg, Bengt (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Laboratory of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden
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- Lundkvist, Åke (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Torkki, Milla (författare)
- Department of Children's Oncology and Hematology Uppsala University Hospital Uppsala Sweden
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- Zhou, Otto (författare)
- Department of Children's Oncology and Hematology Uppsala University Hospital Uppsala Sweden
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- Anderson, Jenna (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning
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- Harila-Saari, Arja H. (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning,Department of Children's Oncology and Hematology Uppsala University Hospital Uppsala Sweden
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- Palle, Josefine, 1964- (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning,Department of Children's Oncology and Hematology Uppsala University Hospital Uppsala Sweden
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(creator_code:org_t)
- 2022-05-25
- 2022
- Engelska.
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Ingår i: Pediatric Blood & Cancer. - : John Wiley & Sons. - 1545-5009 .- 1545-5017. ; 69:10
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundChildren develop symptomatic coronavirus disease 2019 (COVID-19) more rarely than adults upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pediatric oncology and hematology patients may be at increased risk of severe COVID-19 due to their underlying disease or treatment. We investigated COVID-19 and seroprevalence of anti-SARS-CoV-2 antibodies, respectively, in a Swedish cohort of pediatric oncology and hematology patients.ProcedurePatients (n = 136) were recruited between June 2020 and September 2021 at Uppsala University Children's Hospital, Sweden. Up to six consecutive blood samples per patient were analyzed for wild-type anti-S1 IgM and IgG antibodies (including after vaccination, n = 4). Clinical data on COVID-19 (including polymerase chain reaction [PCR] test results) were collected from electronic medical records. A questionnaire was completed at recruitment.ResultsA cumulative seroprevalence (IgM and IgG) of 33% (45/136 patients, 95% confidence interval: 25%–41%) was observed in this patient cohort, of whom 66% (90/136 patients) were under severe immunosuppressive treatment during the study period. Increasing patient age (p = .037) and PCR test results (p < .002) were associated with seropositivity in nonvaccinated cases. Most seropositive, nonvaccinated cases (32/43, 74%) were never PCR-verified for SARS-CoV-2 infection. Of the 13 patients with PCR-verified infection, nine (69%) reported mild disease. A majority (63%) reported continued school attendance during the pandemic.ConclusionsSwedish pediatric oncology and hematology patients developed antibodies against SARS-CoV-2, despite their diagnosis and/or treatment, and the observed seroprevalence was similar to that in national pediatric outpatients. PCR-verified cases underestimate the true incidence of COVID-19 in this patient cohort.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Pediatrik
- Pediatrics
- Infektionssjukdomar
- Infectious Diseases
- Oncology
- Onkologi
- Immunologi
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sundberg, Emil, ...
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Hoffman, Tove
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Nilsson, Anna
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Pahnke, Simon
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Enblad, Gunilla
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Kolstad, Linda
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Rönnberg, Bengt
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Lundkvist, Åke
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Torkki, Milla
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Zhou, Otto
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Anderson, Jenna
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Harila-Saari, Ar ...
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Palle, Josefine, ...
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