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Identification of c...
Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients
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- Shang, Pei (författare)
- Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA.;First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China.
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- Ho, Ada Man-Choi (författare)
- Mayo Clin, Dept Psychiat & Psychol, Coll Med & Sci, Rochester, MN 55905 USA.
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- Tufvesson-Alm, Maximilian (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Lindberg, Daniel R. (författare)
- Mayo Clin, Sch Med & Sci, Mayo Clin MD PhD Program, Rochester, MN USA.;Mayo Clin, Neurosci Program, Coll Med & Sci, Rochester, MN 55905 USA.
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- Grant, Caroline W. (författare)
- Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA.
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- Orhan, Funda (författare)
- Karolinska Institutet
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- Eren, Feride (författare)
- Karolinska Institutet
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- Bhat, Maria (författare)
- AstraZeneca, Sci Life Lab, Res & Dev Innovat Med Personalised Healthcare & B, SE-17177 Solna, Sweden.
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- Engberg, Goran (författare)
- Karolinska Institutet
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- Schwieler, Lilly (författare)
- Karolinska Institutet
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- Fatouros-Bergman, Helena (författare)
- Karolinska Institutet
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- Imbeault, Sophie (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Iverson, Ryan M. (författare)
- Mayo Clin, Div Biomed Stat & Informat, Coll Med, Rochester, MN USA.
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- Dasari, Surendra (författare)
- Mayo Clin, Div Biomed Stat & Informat, Coll Med, Rochester, MN USA.
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- Piehl, Fredrik (författare)
- Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Clin Neurosci,Unit Neuroimmunol, Stockholm, Sweden.
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- Cervenka, Simon (författare)
- Karolinska Institutet,Uppsala universitet,Psykiatri,Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.;Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden.
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- Sellgren, Carl M. (författare)
- Karolinska Institutet
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- Erhardt, Sophie (författare)
- Karolinska Institutet
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- Choi, Doo-Sup (författare)
- Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA.;Mayo Clin, Dept Psychiat & Psychol, Coll Med & Sci, Rochester, MN 55905 USA.;Mayo Clin, Neurosci Program, Coll Med & Sci, Rochester, MN 55905 USA.
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Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Coll Med & Sci, Rochester, MN 55905 USA;First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China. Mayo Clin, Dept Psychiat & Psychol, Coll Med & Sci, Rochester, MN 55905 USA. (creator_code:org_t)
- 2022-06-03
- 2022
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Psychotic disorders are currently diagnosed by examining the patient's mental state and medical history. Identifying reliable diagnostic, monitoring, predictive, or prognostic biomarkers would be useful in clinical settings and help to understand the pathophysiology of schizophrenia. Here, we performed an untargeted metabolomics analysis using ultra-high pressure liquid chromatography coupled with time-of-flight mass spectroscopy on cerebrospinal fluid (CSF) and serum samples of 25 patients at their first-episode psychosis (FEP) manifestation (baseline) and after 18 months (follow-up). CSF and serum samples of 21 healthy control (HC) subjects were also analyzed. By comparing FEP and HC groups at baseline, we found eight CSF and 32 serum psychosis-associated metabolites with non-redundant identifications. Most remarkable was the finding of increased CSF serotonin (5-HT) levels. Most metabolites identified at baseline did not differ between groups at 18-month follow-up with significant improvement of positive symptoms and cognitive functions. Comparing FEP patients at baseline and 18-month follow-up, we identified 20 CSF metabolites and 90 serum metabolites that changed at follow-up. We further utilized Ingenuity Pathway Analysis (IPA) and identified candidate signaling pathways involved in psychosis pathogenesis and progression. In an extended cohort, we validated that CSF 5-HT levels were higher in FEP patients than in HC at baseline by reversed-phase high-pressure liquid chromatography. To conclude, these findings provide insights into the pathophysiology of psychosis and identify potential psychosis-associated biomarkers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Shang, Pei
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Ho, Ada Man-Choi
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Tufvesson-Alm, M ...
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Lindberg, Daniel ...
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Grant, Caroline ...
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Orhan, Funda
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visa fler...
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Eren, Feride
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Bhat, Maria
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Engberg, Goran
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Schwieler, Lilly
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Fatouros-Bergman ...
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Imbeault, Sophie
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Iverson, Ryan M.
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Dasari, Surendra
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Piehl, Fredrik
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Cervenka, Simon
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Sellgren, Carl M ...
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Erhardt, Sophie
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Choi, Doo-Sup
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Translational Ps ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet