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Drug diffusion in b...
Drug diffusion in biomimetic hydrogels : importance for drug transport and delivery in non-vascular tumor tissue
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- Degerstedt, Oliver (författare)
- Uppsala universitet,Institutionen för farmaci
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- Gråsjö, Johan, 1962- (författare)
- Uppsala universitet,Institutionen för farmaci
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- Norberg, Anton (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Sjögren, Erik, 1977- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Hansson, Per (författare)
- Uppsala universitet,Institutionen för farmaci
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- Lennernäs, Hans (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: European Journal of Pharmaceutical Sciences. - : Elsevier. - 0928-0987 .- 1879-0720. ; 172
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Hydrogels of varying complexity are routinely used as scaffolds and 3D structures for in vitro tumor models to increase physiological relevance within pre-clinical cancer research. Relatively simple hydrogels such as agarose are well characterised, meanwhile biomimetic gels containing collagen and fibrin(ogen) have been studied to a much lesser extent. In this study, hydrogels mimicking the biophysical characteristics of liver cancer progression were investigated in terms of their UV-properties and influence on diffusion coefficients of different substances. UV-imaging technology was used to both visualize and quantify the diffusion process in a simple and rapid way. In general, agarose gel diffusion agreed well with predictions using the Stokes-Einstein equation meanwhile the biomimetic gels reduced diffusion coefficients by up to 70%. For doxorubicin, spatio-temporal tissue concentration modelling was used to translate in vitro diffusion to the more clinical context of tumor penetration in a solid liver tumor supplied by arterial blood.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- UV-imaging
- tumor diffusion
- hydrogels
- extracellular matrix
- liver cancer
- doxorubicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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