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Microfluidics platf...
Microfluidics platform for studies of peptide - polyelectrolyte interaction
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- Wanselius, Marcus (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Searle, Sean, 1991- (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Rodler, Agnes (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Tenje, Maria (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för materialvetenskap,EMBLA
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- Abrahmsén-Alami, Susanna (författare)
- AstraZeneca, Innovat Strategies & External Liaison Pharmaceut T, Operat, Gothenburg, Sweden.
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- Hansson, Per (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: International Journal of Pharmaceutics. - : Elsevier. - 0378-5173 .- 1873-3476. ; 621
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Subcutaneous injection is one of the most common approaches for administering biopharmaceuticals unsuitable for oral delivery. However, there is a lack of methods to predict the behavior of biopharmaceuticals within the extracellular matrix of the subcutaneous tissue. In this work, we present a novel miniaturized microfluidic-based in vitro method able to investigate interactions between drug molecules and the polymers of the subcutaneous extracellular matrix. To validate the method, microgels consisting of, respectively, covalently cross-linked hy-aluronic acid, polyacrylic acid, and commercially available DC BeadTM, were exposed to three model substances: cytochrome C, protamine sulfate and amitriptyline hydrochloride. These components were chosen to include systems with widely different physiochemical properties (charge, size, self-assembly, etc.) The experimental results were compared with theoretical predictions from a gel model developed earlier. The results show that the method is suitable as a rapid screening method for automated, large-scale, probing of interactions between biopolymers and drug molecules, with small consumption of material.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Microfluidics
- Microgel
- Subcutaneous administration
- In vitro method
- Polyelectrolyte
- Peptide
- Protein
- Drug
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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