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Gestational Diabete...
Gestational Diabetes Mellitus Risk in Pregnant Women With Systemic Lupus Erythematosus
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- Gernaat, Sofie A. M. (författare)
- Karolinska Institutet
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- Simard, Julia F. (författare)
- Karolinska Univ Hosp, Karolinska Inst, Div Epidemiol, Dept Med Solna, Stockholm, Sweden.;Stanford Sch Med, Div Rheumatol & Immunol, Dept Med, Stanford, CA USA.;Stanford Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA.
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- Wikström, Anna-Karin, 1965- (författare)
- Uppsala universitet,Klinisk obstetrik
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- Svenungsson, Elisabet (författare)
- Karolinska Institutet
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- Arkema, Elizabeth V. (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Univ Hosp, Karolinska Inst, Div Epidemiol, Dept Med Solna, Stockholm, Sweden;Stanford Sch Med, Div Rheumatol & Immunol, Dept Med, Stanford, CA USA.;Stanford Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA. (creator_code:org_t)
- 2021-12-01
- 2022
- Engelska.
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Ingår i: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 49:5, s. 465-469
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: To investigate the risk of gestational diabetes mellitus (GDM) associated with systemic lupus erythematosus (SLE) by comparing pregnancies in women with SLE to general population controls.Methods: We identified singleton pregnancies among women with SLE and general population controls in the Swedish Medical Birth Register (MBR; 2006???2016), sampled from the population-based Swedish Lupus Linkage (SLINK) cohort (1987???2012). SLE was defined by >_ 2 International Classification of Diseases (ICD)-coded visits in the National Patient Register (NPR) and MBR, with >_ 1 visit before pregnancy. GDM was defined by >_ 1 ICD-coded visit in the NPR or MBR. Glucocorticoid (GC) and hydroxychloroquine (HCQ) dispensations within 6 months before and during pregnancy were identified in the Prescribed Drug Register. Risk ratios (RRs) and 95% CIs of GDM associated with SLE were estimated using modified Poisson regression models, stratified by parity and adjusted for maternal age at delivery, year of birth, and obesity.Results: We identified 695 SLE pregnancies including 18 (2.6%) with GDM and 4644 non-SLE pregnancies including 65 (1.4%) with GDM. Adjusted RRs of GDM associated with SLE were 1.11 (95% CI 0.38???3.27) for first deliveries and 2.03 (95% CI 1.21???3.40) for all deliveries. Among SLE pregnancies, GDM occurred in 7/306 (2.3%) with >_ 1 GC before and/or during pregnancy, 11/389 (2.8%) without GC, 7/287 (2.4%) with >_ 1 HCQ before and/or during pregnancy, and in 11/408 (2.7%) without HCQ.Conclusion: When looking at all deliveries, SLE was associated with a 2-fold higher risk of GDM. GDM occurrence did not differ by GC or HCQ.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- gestational diabetes
- glucocorticoids
- pregnancy
- systemic lupus erythematosus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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