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Sökning: onr:"swepub:oai:DiVA.org:uu-478866" > Obesity I :

  • Lustig, Robert H.Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA. (författare)

Obesity I : Overview and molecular and biochemical mechanisms

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-478866
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478866URI
  • https://doi.org/10.1016/j.bcp.2022.115012DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence has increased globally since the 1970s, and the number of obese and overweight people is now greater than those underweight. Obesity is a multifactorial condition, and as such, many components contribute to its development and pathogenesis. This is the first of three companion reviews that consider obesity. This review focuses on the genetics, viruses, insulin resistance, inflammation, gut microbiome, and circadian rhythms that promote obesity, along with hormones, growth factors, and organs and tissues that control its development. It shows that the regulation of energy balance (intake vs. expenditure) relies on the interplay of a variety of hormones from adipose tissue, gastrointestinal tract, pancreas, liver, and brain. It details how integrating central neurotransmitters and peripheral metabolic signals (e.g., leptin, insulin, ghrelin, peptide YY3-36) is essential for controlling energy homeostasis and feeding behavior. It describes the distinct types of adipocytes and how fat cell development is controlled by hormones and growth factors acting via a variety of receptors, including peroxisome proliferator-activated receptor-gamma, retinoid X, insulin, estrogen, androgen, glucocorticoid, thyroid hormone, liver X, constitutive androstane, pregnane X, farnesoid, and aryl hydrocarbon receptors. Finally, it demonstrates that obesity likely has origins in utero. Understanding these biochemical drivers of adiposity and metabolic dysfunction throughout the life cycle lends plausibility and credence to the "obesogen hypothesis " (i.e., the importance of environmental chemicals that disrupt these receptors to promote adiposity or alter metabolism), elucidated more fully in the two companion reviews.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Collier, DavidEast Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA. (författare)
  • Kassotis, ChristopherWayne State Univ, Inst Environm Hlth Sci, Dept Pharmacol, Detroit, MI 48202 USA. (författare)
  • Roepke, Troy A.Rutgers State Univ, Sch Environm & Biol Sci, New Brunswick, NJ 08901 USA. (författare)
  • Kim, Min JiSorbonne Paris Nord Univ, INSERM U1124 (T3S), Bobigny, Paris, France. (författare)
  • Blanc, EtienneUniv Paris, Dept Biochem & Toxicol, INSERM U1224 T3S, F-75006 Paris, France. (författare)
  • Barouki, RobertUniv Paris, Dept Biochem & Toxicol, INSERM U1224 T3S, F-75006 Paris, France. (författare)
  • Bansal, AmitaAustralian Natl Univ, Coll Hlth & Med, Canberra, Australia. (författare)
  • Cave, Matthew C.Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA. (författare)
  • Chatterjee, SaurabhUniv South Carolina, Environm Hlth & Dis Lab, Columbia, SC 29208 USA. (författare)
  • Choudhury, MahuaTexas A&M Univ, Coll Pharm, College Stn, TX 77843 USA. (författare)
  • Gilbertson, MichaelUniv Stirling, Occupat & Environm Hlth Res Grp, Stirling, Scotland. (författare)
  • Lagadic-Gossmann, DominiqueUniv Rennes, INSERM, EHESP, IRSET-UMR S 1085, F-35000 Rennes, France. (författare)
  • Howard, SarahHlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA. (författare)
  • Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind (författare)
  • Tomlinson, Craig R.Norris Cotton Canc Ctr, Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Lebanon, NH 03756 USA. (författare)
  • Vondracek, JanInst Biophys Czech Acad Sci, Dept Cytokinet, Brno, Czech Republic. (författare)
  • Heindel, Jerrold J.Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA.;HEEDS, Commonweal, 451 Mesa Rd, Bolinas, CA 92924 USA. (författare)
  • Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA.East Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biochemical Pharmacology: Elsevier1990006-29521356-1839

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