Sökning: onr:"swepub:oai:DiVA.org:uu-479456" >
Obesity as a predic...
Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia
-
- Egnell, Christina (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
-
- Heyman, Mats (författare)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
-
- Jonsson, Olafur Gisli (författare)
- Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland.
-
visa fler...
-
- Raja, Raheel A. (författare)
- Univ Hosp Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark.
-
- Niinimaki, Riitta (författare)
- Oulu Univ Hosp, Med Res Ctr Oulu, PEDEGO Res Unit, Oulu, Finland.;Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland.;Univ Oulu, Oulu, Finland.
-
- Albertsen, Birgitte Klug (författare)
- Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
-
- Schmiegelow, Kjeld (författare)
- Univ Hosp Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark.
-
- Stabell, Niklas (författare)
- Univ Hosp North Norway, Dept Paediat, Tromso, Norway.
-
- Vaitkeviciene, Goda (författare)
- Santaros Klin & Vilnius Univ, Childrens Hosp, Affiliate Vilnius Univ Hosp, Vilnius, Lithuania.
-
- Lepik, Kristi (författare)
- Childrens Hosp, Dept Haematol & Oncol, Tallinn, Estonia.
-
- Harila-Saari, Arja H. (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning
-
- Ranta, Susanna (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
-
visa färre...
-
Karolinska Institutet Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden. (creator_code:org_t)
- 2021-11-02
- 2022
- Engelska.
-
Ingår i: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 196:5, s. 1239-1247
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2 center dot 0-17 center dot 9 years with ALL treated with the Nordic Society of Pediatric Haematology and Oncology (NOPHO) ALL2008 non-high-risk protocol. Prospective treatment-related toxicities registered every three-month interval were used. Patients were classified according to sex- and age-adjusted international childhood cut-off values, corresponding to adult body mass index: underweight, <17 kg/m(2); healthy weight, 17 to <25 kg/m(2); overweight, 25 to <30 kg/m(2); and obese, >= 30 kg/m(2). Obese children had a higher incidence rate ratio (IRR) for severe toxic events {IRR: 1 center dot 55 [95% confidence interval (CI) 1 center dot 07-2 center dot 50]}, liver and kidney failures, bleeding, abdominal complication, suspected unexpected severe adverse reactions and hyperlipidaemia compared with healthy-weight children. Obese children aged >= 10 years had increased IRRs for asparaginase-related toxicities compared with healthy-weight older children: thromboses [IRR 2 center dot 87 (95% CI 1 center dot 00-8 center dot 21)] and anaphylactic reactions [IRR 7 center dot 95 (95% CI 2 center dot 15-29 center dot 37)] as well as higher risk for truncation of asparaginase [IRR 3 center dot 54 (95% CI 1 center dot 67-7 center dot 50)]. The high prevalence of toxicity and a higher risk of truncation of asparaginase may play a role in the poor prognosis of obese children aged >= 10 years with ALL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- body mass index
- obesity
- childhood acute lymphoblastic leukaemia
- adverse events
- toxicity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Egnell, Christin ...
-
Heyman, Mats
-
Jonsson, Olafur ...
-
Raja, Raheel A.
-
Niinimaki, Riitt ...
-
Albertsen, Birgi ...
-
visa fler...
-
Schmiegelow, Kje ...
-
Stabell, Niklas
-
Vaitkeviciene, G ...
-
Lepik, Kristi
-
Harila-Saari, Ar ...
-
Ranta, Susanna
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
British Journal ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet