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Gaseous air polluta...
Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of US adults
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- Holliday, Katelyn M. (författare)
- Duke Univ, Sch Med, Dept Family Med & Community Hlth, Durham, NC USA.;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
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- Gondalia, Rahul (författare)
- Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
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- Baldassari, Antoine (författare)
- Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
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visa fler...
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- Justice, Anne E. (författare)
- Geisinger Hlth Syst, Danville, PA USA.
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- Stewart, James D. (författare)
- Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
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- Liao, Duanping (författare)
- Penn State Univ, Dept Publ Hlth Sci, Coll Med, Div Epidemiol, Hershey, PA USA.
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- Yanosky, Jeff D. (författare)
- Penn State Univ, Dept Publ Hlth Sci, Coll Med, Div Epidemiol, Hershey, PA USA.
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- Jordahl, Kristina M. (författare)
- Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA.
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- Bhatti, Parveen (författare)
- BC Canc, Canc Control Res, Vancouver, BC, Canada.
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- Assimes, Themistocles L. (författare)
- Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.
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- Pankow, James S. (författare)
- Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
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- Guan, Weihua (författare)
- Univ Minnesota, Div Biostat, Minneapolis, MN USA.
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- Fornage, Myriam (författare)
- Univ Texas Hlth Sci Ctr Houston, Brown Fdn, Inst Mol Med, McGovern Med Sch, Houston, TX 77030 USA.;Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA.
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- Bressler, Jan (författare)
- Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA.
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- North, Kari E. (författare)
- Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
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- Conneely, Karen N. (författare)
- Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA USA.
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- Li, Yun (författare)
- Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27515 USA.
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- Hou, Lifang (författare)
- Northwestern Univ Chicago, Feinberg Sch Med, Dept Prevent Med, Evanston, IL USA.;Northwestern Univ Chicago, Ctr Populat Epigenet, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Evanston, IL USA.
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- Vokonas, Pantel S. (författare)
- Boston Univ, Sch Med, VA Normat Aging Study, VA Boston Healthcare Syst, Boston, MA 02118 USA.;Boston Univ, Sch Publ Hlth, VA Normat Aging Study, VA Boston Healthcare Syst, Boston, MA 02118 USA.
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- Ward-Caviness, Cavin K. (författare)
- Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27514 USA.
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- Wilson, Rory (författare)
- German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
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- Wolf, Kathrin (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
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- Waldenberger, Melanie (författare)
- German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
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- Cyrys, Josef (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
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- Peters, Annette (författare)
- German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Med Fac, Inst Med Informat Proc Biometry & Epidemiol, Munich, Germany.
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- Boezen, H. Marike (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands.
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- Vonk, Judith M. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands.
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- Sayols-Baixeras, Sergi (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Pompeu Fabra, Hosp Mar, Cardiovasc Epidemiol & Genet Res Grp, Med Res Inst IMIM, Campus Mar, Barcelona, Spain.;Inst Salud Carlos III, MP Enfermedades Cardiovasc CIBERCV, Consorcio CIBER, Madrid, Spain.
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- Lee, Mikyeong (författare)
- NIEHS, Epidemiol Branch, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA.
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- Baccarelli, Andrea A. (författare)
- Columbia Univ, Dept Environm Hlth Sci, Lab Environm Epigenet, Mailman Sch Publ Hlth, New York, NY USA.;Columbia Univ, Dept Epidemiol, Lab Environm Epigenet, Mailman Sch Publ Hlth, New York, NY USA.
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- Whitsel, Eric A. (författare)
- Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.;Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA.
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Duke Univ, Sch Med, Dept Family Med & Community Hlth, Durham, NC USA;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 212
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Epigenetic mechanisms may underlie air pollution-health outcome associations. We estimated gaseous air pollutant-DNA methylation (DNAm) associations using twelve subpopulations within Women's Health Initiative (WHI) and Atherosclerosis Risk in Communities (ARIC) cohorts (n = 8397; mean age 61.3 years; 83% female; 46% African-American, 46% European-American, 8% Hispanic/Latino). We used geocoded participant address-specific mean ambient carbon monoxide (CO), nitrogen oxides (NO2; NOx), ozone (O-3), and sulfur dioxide (SO2) concentrations estimated over the 2-, 7-, 28-, and 365-day periods before collection of blood samples used to generate Illumina 450 k array leukocyte DNAm measurements. We estimated methylome-wide, subpopulation-and race/ethnicity-stratified pollutant-DNAm associations in multi-level, linear mixed-effects models adjusted for sociodemographic, behavioral, meteorological, and technical covariates. We combined stratum-specific estimates in inverse variance-weighted meta-analyses and characterized significant associations (false discovery rate; FDR<0.05) at Cytosine-phosphate-Guanine (CpG) sites without among-strata heterogeneity (P-Cochran's Q > 0.05). We attempted replication in the Cooperative Health Research in Region of Augsburg (KORA) study and Normative Aging Study (NAS). We observed a -0.3 (95% CI: -0.4, -0.2) unit decrease in percent DNAm per interquartile range (IQR, 7.3 ppb) increase in 28-day mean NO2 concentration at cg01885635 (chromosome 3; regulatory region 290 bp upstream from ZNF621; FDR = 0.03). At intragenic sites cg21849932 (chromosome 20; LIME1; intron 3) and cg05353869 (chromosome 11; KLHL35; exon 2), we observed a -0.3 (95% CI: -0.4, -0.2) unit decrease (FDR = 0.04) and a 1.2 (95% CI: 0.7, 1.7) unit increase (FDR = 0.04), respectively, in percent DNAm per IQR (17.6 ppb) increase in 7-day mean ozone concentration. Results were not fully replicated in KORA and NAS. We identified three CpG sites potentially susceptible to gaseous air pollution-induced DNAm changes near genes relevant for cardiovascular and lung disease. Further harmonized investigations with a range of gaseous pollutants and averaging durations are needed to determine the effect of gaseous air pollutants on DNA methylation and ultimately gene expression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Air pollution
- DNA methylation
- Epigenetics
- Epigenome-wide association study
- Gaseous pollutants
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- Av författaren/redakt...
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Holliday, Kately ...
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Gondalia, Rahul
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Baldassari, Anto ...
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Justice, Anne E.
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Stewart, James D ...
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Liao, Duanping
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visa fler...
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Yanosky, Jeff D.
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Jordahl, Kristin ...
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Bhatti, Parveen
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Assimes, Themist ...
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Pankow, James S.
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Guan, Weihua
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Fornage, Myriam
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Bressler, Jan
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North, Kari E.
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Conneely, Karen ...
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Li, Yun
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Hou, Lifang
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Vokonas, Pantel ...
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Ward-Caviness, C ...
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Wilson, Rory
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Wolf, Kathrin
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Waldenberger, Me ...
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Cyrys, Josef
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Peters, Annette
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Boezen, H. Marik ...
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Vonk, Judith M.
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Sayols-Baixeras, ...
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Lee, Mikyeong
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Baccarelli, Andr ...
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Whitsel, Eric A.
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