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Mortality and Cardi...
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Figtree, Gemma A.Royal North Shore Hosp, Kolling Inst, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.;Royal North Shore Hosp, Dept Cardiol, Sydney, NSW, Australia,Royal North Shore Hospital
(författare)
Mortality and Cardiovascular Outcomes in Patients Presenting With Non-ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors : Results From the SWEDEHEART Registry
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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John Wiley & Sons,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-482399
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482399URI
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https://doi.org/10.1161/JAHA.121.024818DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187305URI
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https://lup.lub.lu.se/record/28672bc7-b61d-408d-b71e-27fa26eee31dURI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Correction in: Journal of the American Heart Association, Vol. 12, Issue. 7DOI: 10.1161/JAHA.121.027668
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Funding Agencies|Swedish Heart and Lung Foundation; National Health and Medical Research Council (Australia); Heart Research Australia; NSW Office of Health and Medical Research; National Health and Medical Research Council of Australia; National Heart Foundation of Australia [FLF102056]; National Health and Medical Research Council of Australia [CDF1161506]
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Background A significant proportion of patients with ST-segment-elevation myocardial infarction (MI) have no standard modifiable cardiovascular risk factors (SMuRFs) and have unexpected worse 30-day outcomes compared with those with SMuRFs. The aim of this article is to examine outcomes of patients with non-ST-segment-elevation MI in the absence of SMuRFs.Methods and Results Presenting features, management, and outcomes of patients with non-ST-segment-elevation MI without SmuRFs (hypertension, diabetes, hypercholesterolemia, smoking) were compared with those with SmuRFs in the Swedish MI registry SWEDEHEART (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies; 2005-2018). Cox proportional hazard models were used. Out of 99 718 patients with non-ST-segment-elevation MI, 11 131 (11.2%) had no SMuRFs. Patients without SMuRFs had higher all-cause and cardiovascular mortality at 30 days (hazard ratio [HR], 1.20 [95% CI, 1.10-1.30], P<0.0001; and HR, 1.25 [95% CI, 1.13-1.38]), a difference that remained after adjustment for age and sex. SMuRF-less patients were less likely to receive secondary prevention statins (76% versus 82%); angiotensin-converting enzyme inhibitors/angiotensin receptor blockade (54% versus 72%); or beta-blockers (81% versus 87%, P for all <0.0001), with lowest rates observed in women without SMuRFs. In patients who survived to 30 days, rates of all-cause and cardiovascular death were lower in patients without SMuRFs compared with those with risk factors, over 12 years.Conclusions One in 10 patients presenting with non-ST-segment-elevation MI present without traditional risk factors. The excess 30-day mortality rate in this group emphasizes the need for both improved population-based strategies for prevention of MI, as well as the need for equitable evidence-based treatment at the time of an MI.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Vernon, Stephen T.Royal North Shore Hosp, Kolling Inst, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.;Royal North Shore Hosp, Dept Cardiol, Sydney, NSW, Australia,Royal North Shore Hospital
(författare)
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Hadziosmanovic, NerminUppsala University,Uppsala universitet,Kardiologi,Uppsala Univ, Sweden(Swepub:uu)nerha973
(författare)
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Sundström, Johan,Professor,1971-Uppsala University,Uppsala universitet,Klinisk epidemiologi,UNSW Sydney, George Inst Global Hlth, Sydney, NSW, Australia,Uppsala Univ, Sweden; UNSW Sydney, Australia,University of New South Wales(Swepub:uu)johasund
(författare)
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Alfredsson, JoakimLinköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)joaal38
(författare)
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Nicholls, Stephen J.Monash Univ, Monash Cardiovasc Res Ctr, Victorian Heart Inst, Clayton, Vic, Australia,Monash University
(författare)
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Chow, Clara K.Univ Sydney, Westmead Appl Res Ctr, Fac Med & Hlth, Sydney, NSW, Australia.;Westmead Hosp, Dept Cardiol, Sydney, NSW, Australia,Westmead Hospital,University of Sydney
(författare)
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Psaltis, PeterUniv Adelaide, Vasc Res Ctr, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia.;Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia,University of Adelaide
(författare)
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Røsjø, HelgeUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Akershus Univ Hosp, Lorenskog, Norway; Univ Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway; Uppsala Clin Res Ctr, Sweden,Akershus University Hospital,University of Oslo
(författare)
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Leosdottir, MargretLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-mle
(författare)
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Hagström, EmilUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Royal North Shore Hosp, Dept Cardiol, Sydney, NSW, Australia,Royal North Shore Hosp, Australia; Uppsala Clin Res Ctr, Sweden,Royal North Shore Hospital(Swepub:uu)emhag677
(författare)
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Royal North Shore Hosp, Kolling Inst, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.;Royal North Shore Hosp, Dept Cardiol, Sydney, NSW, AustraliaRoyal North Shore Hospital
(creator_code:org_t)
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Ingår i:Journal of the American Heart Association: John Wiley & Sons11:152047-9980
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Figtree, Gemma A ...
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Vernon, Stephen ...
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Alfredsson, Joak ...
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Nicholls, Stephe ...
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Chow, Clara K.
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Psaltis, Peter
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Røsjø, Helge
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