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The burden of mild ...
The burden of mild asthma : Clinical burden and healthcare resource utilisation in the NOVELTY study
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- Golam, Sarowar Muhammad (författare)
- AstraZeneca, GMAP, BioPharmaceut R&D, Gothenburg, Sweden.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Beasley, Richard (författare)
- Med Res Inst New Zealand, Wellington, New Zealand.
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- FitzGerald, J. Mark (författare)
- Vancouver Gen Hosp, Vancouver Coastal Hlth Res Inst, Ctr Lung Hlth, Lung Ctr, Vancouver, BC, Canada.
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- Harrison, Tim (författare)
- Nottingham City Hosp, Fac Med & Hlth Sci, Nottingham, Nottinghamshire, England.
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- Chipps, Bradley (författare)
- Capital Allergy & Resp Dis Ctr, Sacramento, CA USA.
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- Hughes, Rod (författare)
- AstraZeneca, External Sci Engagement, BioPharmaceut Med, Cambridge, Cambridgeshire, England.;AstraZeneca PLC, Melbourne Sci Pk, Royston SG8 6HB, Hertfordshire, England.
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- Mullerov, Hana (författare)
- AstraZeneca, Resp & Immunol Med & Payer Evidence Strategy, BioPharmaceut Med, Cambridge, Cambridgeshire, England.
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- Olaguibel, Jose Maria (författare)
- Complejo Hosp Navarra, Severe Asthma Unit, Pamplona, Spain.
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- Rapsomaniki, Eleni (författare)
- AstraZeneca, Real World Data Sci, BioPharmaceut Med, Cambridge, Cambridgeshire, England.
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- Reddel, Helen K. (författare)
- Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.
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- Sadatsafavi, Mohsen (författare)
- Univ British Columbia, Fac Pharmaceut Sci, Resp Evaluat Sci Program, Vancouver, BC, Canada.
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NOVELTY invest, N. O. V. E. L. T. Y. investigators (författare)
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AstraZeneca, GMAP, BioPharmaceut R&D, Gothenburg, Sweden Lung- allergi- och sömnforskning (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 200
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Patients with mild asthma represent a substantial proportion of the population with asthma, yet there are limited data on their true burden of disease. We aimed to describe the clinical and healthcare resource utilisation (HCRU) burden of physician-assessed mild asthma.Methods: Patients with mild asthma were included from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329), a global, 3-year, real-world prospective study of patients with asthma and/or chronic obstructive pulmonary disease from community practice (specialised and primary care). Diagnosis and severity were based on physician discretion. Clinical burden included physician-reported exacerbations and patient-reported measures. HCRU included inpatient and outpatient visits.Results: Overall, 2004 patients with mild asthma were included; 22.8% experienced >= 1 exacerbation in the previous 12 months, of whom 72.3% experienced >= 1 severe exacerbation. Of 625 exacerbations reported, 48.0% lasted >1 week, 27.7% were preceded by symptomatic worsening lasting >3 days, and 50.1% required oral corticosteroid treatment. Health status was moderately impacted (St George's Respiratory Questionnaire score: 23.5 [standard deviation +/- 17.9]). At baseline, 29.7% of patients had asthma symptoms that were not well controlled or very poorly controlled (Asthma Control Test score <20), increasing to 55.6% for those with >= 2 exacerbations in the previous year. In terms of HCRU, at least one unscheduled ambulatory visit for exacerbations was required by 9.5% of patients, including 9.2% requiring >= 1 emergency department visit and 1.1% requiring >= 1 hospital admission.Conclusions: In this global sample representing community practice, a significant proportion of patients with physician-assessed mild asthma had considerable clinical burden and HCRU.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Disease burden
- Healthcare resource utilisation
- Longitudinal studies
- Mild asthma
- Patient-reported measures
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- Av författaren/redakt...
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Golam, Sarowar M ...
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Janson, Christer
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Beasley, Richard
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FitzGerald, J. M ...
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Harrison, Tim
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Chipps, Bradley
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visa fler...
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Hughes, Rod
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Mullerov, Hana
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Olaguibel, Jose ...
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Rapsomaniki, Ele ...
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Reddel, Helen K.
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Sadatsafavi, Moh ...
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NOVELTY invest, ...
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Uppsala universitet