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Repeated Measures o...
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Chye, Alexander
(författare)
Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke : AFFINITY Study Findings
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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Ovid Technologies (Wolters Kluwer Health),2022
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-484032
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-484032URI
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https://doi.org/10.1161/JAHA.121.025425DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We compare repeated-measures and single-measure analyses of the mRS from a randomized clinical trialMethods and Results: Serial mRS data from AFFINITY (Assessment of Fluoxetine in Stroke Recovery), a double-blind placebo randomized clinical trial of fluoxetine following stroke (n=1280) were analyzed to identify demographic and clinical associations with functional recovery (reduction in mRS) over 12 months. Associations were identified using single-measure (day 365) and repeated-measures (days 28, 90, 180, and 365) partial proportional odds logistic regression. Ninety-five percent of participants experienced a reduction in mRS after 12 months. Functional recovery was associated with age at stroke <70 years; no prestroke history of diabetes, coronary heart disease, or ischemic stroke; prestroke history of depression, a relationship partner, living with others, independence, or paid employment; no fluoxetine intervention; ischemic stroke (compared with hemorrhagic); stroke treatment in Vietnam (compared with Australia or New Zealand); longer time since current stroke; and lower baseline National Institutes of Health Stroke Scale & Patient Health Questionnaire-9 scores. Direction of associations was largely concordant between single-measure and repeated-measures models. Association strength and variance was generally smaller in the repeated-measures model compared with the single-measure model.Conclusions: Repeated-measures may improve trial precision in identifying trial associations and effects. Further repeated-measures stroke analyses are required to prove methodological value. Registration URL: http://www.anzctr.org.au; Unique identifier: ACTRN12611000774921.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hackett, Maree L
(författare)
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Hankey, Graeme J
(författare)
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Lundström, Erik,1964-Uppsala universitet,Neurologi(Swepub:uu)erlun676
(författare)
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Almeida, Osvaldo P
(författare)
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Gommans, John
(författare)
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Dennis, Martin
(författare)
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Jan, Stephen
(författare)
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Mead, Gillian E
(författare)
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Ford, Andrew H
(författare)
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Beer, Christopher Etherton
(författare)
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Flicker, Leon
(författare)
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Delcourt, Candice
(författare)
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Billot, Laurent
(författare)
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Anderson, Craig S
(författare)
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Stibrant Sunnerhagen, Katharina
(författare)
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Yi, Qilong
(författare)
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Bompoint, Severine
(författare)
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Nguyen, Thang Huy
(författare)
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Lung, Thomas
(författare)
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Uppsala universitetNeurologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of the American Heart Association: Ovid Technologies (Wolters Kluwer Health)11:162047-9980
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Chye, Alexander
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Hackett, Maree L
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Hankey, Graeme J
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Lundström, Erik, ...
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Almeida, Osvaldo ...
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Gommans, John
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visa fler...
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Dennis, Martin
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Jan, Stephen
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Mead, Gillian E
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Ford, Andrew H
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Beer, Christophe ...
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Flicker, Leon
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Delcourt, Candic ...
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Billot, Laurent
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Anderson, Craig ...
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Stibrant Sunnerh ...
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Yi, Qilong
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Bompoint, Severi ...
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Nguyen, Thang Hu ...
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Lung, Thomas
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