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Trans Fatty Acid Bi...
Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes : Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)
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- Lai, Heidi T. M. (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.
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- Imamura, Fumiaki (författare)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Korat, Andres V. Ardisson (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Murphy, Rachel A. (författare)
- Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
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- Tintle, Nathan (författare)
- Dordt Univ, Dept Math & Stat, Sioux Ctr, IA USA.;Fatty Acid Res Inst, Sioux Falls, SD USA.
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- Bassett, Julie K. (författare)
- Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.
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- Chen, Jiaying (författare)
- Brigham & Womens Hosp, Div Aging, Boston, MA USA.
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- Kröger, Janine (författare)
- German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.
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- Chien, Kuo-Liong (författare)
- Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.
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- Senn, Mackenzie (författare)
- ARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA.
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- Wood, Alexis C. (författare)
- ARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA.
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- Forouhi, Nita G. (författare)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Schulze, Matthias B. (författare)
- German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany.;Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.
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- Harris, William S. (författare)
- Fatty Acid Res Inst, Sioux Falls, SD USA.;Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.
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- Vasan, Ramachandran S. (författare)
- Boston Univ, Sch Med, Boston, MA 02118 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA.
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- Hu, Frank (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Giles, Graham G. (författare)
- Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.
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- Hodge, Allison (författare)
- Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.
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- Djousse, Luc (författare)
- Harvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA USA.
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- Brouwer, Ingeborg A. (författare)
- Vrije Univ Amsterdam, Fac Sci, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands.
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- Qian, Frank (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
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- Sun, Qi (författare)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Wu, Jason H. Y. (författare)
- Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.
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- Marklund, Matti (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA; Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia
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- Lemaitre, Rozenn N. (författare)
- Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
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- Siscovick, David S. (författare)
- New York Acad Med, New York, NY USA.
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- Fretts, Amanda M. (författare)
- Univ Washington, Dept Epidemiol, Sch Publ Hlth, Cardiovasc Hlth Res Unit, Seattle, WA USA.
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- Shadyab, Aladdin H. (författare)
- Univ Calif San Diego, Sch Med, Family Med & Publ Hlth, La Jolla, CA 92093 USA.
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- Manson, JoAnn E. (författare)
- Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
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- Howard, Barbara, V (författare)
- Georgetown Univ, Med Ctr, Hyattsville, MD USA.
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- Robinson, Jennifer G. (författare)
- Univ Iowa, Iowa City, IA USA.
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- Wallace, Robert B. (författare)
- Univ Iowa, Iowa City, IA USA.
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- Wareham, Nick J. (författare)
- Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Chen, Yii-Der Ida (författare)
- Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.
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- Rotter, Jerome, I (författare)
- Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.
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- Tsai, Michael Y. (författare)
- Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
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- Micha, Renata (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.
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- Mozaffarian, Dariush (författare)
- Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.
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Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England. Univ Cambridge, MRC Epidemiol Unit, Cambridge, England. (creator_code:org_t)
- 2022-02-10
- 2022
- Engelska.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 45:4, s. 854-863
- Relaterad länk:
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https://diabetesjour...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.RESEARCH DESIGN AND METHODS: We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged >= 18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.RESULTS: During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P >= 0.1).CONCLUSIONS: Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Lai, Heidi T. M.
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Imamura, Fumiaki
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Korat, Andres V. ...
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Murphy, Rachel A ...
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Tintle, Nathan
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Bassett, Julie K ...
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visa fler...
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Chen, Jiaying
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Kröger, Janine
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Chien, Kuo-Liong
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Senn, Mackenzie
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Wood, Alexis C.
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Forouhi, Nita G.
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Schulze, Matthia ...
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Harris, William ...
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Vasan, Ramachand ...
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Hu, Frank
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Giles, Graham G.
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Hodge, Allison
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Djousse, Luc
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Brouwer, Ingebor ...
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Qian, Frank
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Sun, Qi
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Wu, Jason H. Y.
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Marklund, Matti
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Lemaitre, Rozenn ...
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Siscovick, David ...
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Fretts, Amanda M ...
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Shadyab, Aladdin ...
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Manson, JoAnn E.
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Howard, Barbara, ...
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Robinson, Jennif ...
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Wallace, Robert ...
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Wareham, Nick J.
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Chen, Yii-Der Id ...
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Rotter, Jerome, ...
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Tsai, Michael Y.
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Micha, Renata
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Mozaffarian, Dar ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Diabetes Care
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Uppsala universitet