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Sökning: onr:"swepub:oai:DiVA.org:uu-484219" > Trans Fatty Acid Bi...

  • Lai, Heidi T. M.Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England. (författare)

Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes : Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-02-10
  • American Diabetes Association,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-484219
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-484219URI
  • https://doi.org/10.2337/dc21-1756DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECTIVE: Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.RESEARCH DESIGN AND METHODS: We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged >= 18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.RESULTS: During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P >= 0.1).CONCLUSIONS: Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Imamura, FumiakiUniv Cambridge, MRC Epidemiol Unit, Cambridge, England. (författare)
  • Korat, Andres V. ArdissonHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA. (författare)
  • Murphy, Rachel A.Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada. (författare)
  • Tintle, NathanDordt Univ, Dept Math & Stat, Sioux Ctr, IA USA.;Fatty Acid Res Inst, Sioux Falls, SD USA. (författare)
  • Bassett, Julie K.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia. (författare)
  • Chen, JiayingBrigham & Womens Hosp, Div Aging, Boston, MA USA. (författare)
  • Kröger, JanineGerman Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany. (författare)
  • Chien, Kuo-LiongNatl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan. (författare)
  • Senn, MackenzieARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA. (författare)
  • Wood, Alexis C.ARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA. (författare)
  • Forouhi, Nita G.Univ Cambridge, MRC Epidemiol Unit, Cambridge, England. (författare)
  • Schulze, Matthias B.German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany.;Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany. (författare)
  • Harris, William S.Fatty Acid Res Inst, Sioux Falls, SD USA.;Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA. (författare)
  • Vasan, Ramachandran S.Boston Univ, Sch Med, Boston, MA 02118 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA. (författare)
  • Hu, FrankHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA. (författare)
  • Giles, Graham G.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia. (författare)
  • Hodge, AllisonCanc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia. (författare)
  • Djousse, LucHarvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA USA. (författare)
  • Brouwer, Ingeborg A.Vrije Univ Amsterdam, Fac Sci, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands. (författare)
  • Qian, FrankHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. (författare)
  • Sun, QiHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA. (författare)
  • Wu, Jason H. Y.Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia. (författare)
  • Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA; Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia(Swepub:uu)matma701 (författare)
  • Lemaitre, Rozenn N.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA. (författare)
  • Siscovick, David S.New York Acad Med, New York, NY USA. (författare)
  • Fretts, Amanda M.Univ Washington, Dept Epidemiol, Sch Publ Hlth, Cardiovasc Hlth Res Unit, Seattle, WA USA. (författare)
  • Shadyab, Aladdin H.Univ Calif San Diego, Sch Med, Family Med & Publ Hlth, La Jolla, CA 92093 USA. (författare)
  • Manson, JoAnn E.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. (författare)
  • Howard, Barbara, VGeorgetown Univ, Med Ctr, Hyattsville, MD USA. (författare)
  • Robinson, Jennifer G.Univ Iowa, Iowa City, IA USA. (författare)
  • Wallace, Robert B.Univ Iowa, Iowa City, IA USA. (författare)
  • Wareham, Nick J.Univ Cambridge, MRC Epidemiol Unit, Cambridge, England. (författare)
  • Chen, Yii-Der IdaHarbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA. (författare)
  • Rotter, Jerome, IHarbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA. (författare)
  • Tsai, Michael Y.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA. (författare)
  • Micha, RenataTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA. (författare)
  • Mozaffarian, DariushTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA. (författare)
  • Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.Univ Cambridge, MRC Epidemiol Unit, Cambridge, England. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes Care: American Diabetes Association45:4, s. 854-8630149-59921935-5548

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