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Copper-mediated iso...
Copper-mediated isotopic exchange between [125I]iodide and bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate in aqueous media
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- Schukin, E. (författare)
- Uppsala universitet,Kemiska institutionen
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- Orlova, Anna (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
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Korsakov, M. (författare)
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Sjöberg, Stefan (författare)
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- Tolmachev, Vladimir (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
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(creator_code:org_t)
- 2004
- 2004
- Engelska.
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Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - 0236-5731 .- 1588-2780. ; 260:2, s. 295-299
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Derivatives of dodecahydro-closo-dodecaborate(2-) anion were proposed as boron-rich compounds for boron-neutron capture therapy (BNCT) of malignant tumours. Labeling of such tumour-targeting compounds with radioisotopes would facilitate the investigation of their pharmacokinetics and help to optimize patient treatment protocols. Earlier, we reported the feasibility of labeling of closo-dodecaborate(2-) by isotopic exchange in molten acetamide. In this study, the feasibility of low-temperature isotopic exchange in the system [125I]iodide - bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate was investigated. Our attempts to perform the exchange in solvents such as methylene chloride, acetone and acetonitrile in the presence of phase-transfer catalysts were unsuccessful. However, copper mediated exchange in aqueous media was possible. Isotopic exchange of triethylammonium undecahydro-12-iodo-closo-dodecaborate provided a 90-95% labeling yield after heating for three and half hours at 100 °C.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Organic chemistry
- Organisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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