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Joint Exposure to P...
Joint Exposure to Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism and Incident Type 2 Diabetes
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- Sun, Ying (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Yu, Yuefeng (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Zhang, Haojie (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Wang, Bin (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Chen, Chi (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Wang, Yuying (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Tan, Xiao (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap,Karolinska Inst, Dept Clin Neurosci, Solna, Sweden.
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- Zhang, Jihui (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China.
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- Chen, Yi (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Xia, Fangzhen (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Lu, Yingli (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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- Wang, Ningjian (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
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Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China Institutionen för neurovetenskap (creator_code:org_t)
- 2022-05-12
- 2022
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:8, s. E3186-E3193
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Context Whether the psychological wellbeing status could be a risk factor for type 2 diabetes is unclear. Objective We aimed to measure the association between combined psychological wellbeing factors and type 2 diabetes and investigate whether this association was modified by genetic predisposition. Methods Prospective cohort study from the UK Biobank. In total, 127 496 participants who completed a psychological wellbeing questionnaire and did not have type 2 diabetes at baseline (2006-2010) were included; among them, 88 584 (69.5%) were analyzed to determine their genetic predisposition. The main outcome measure was incident type 2 diabetes. Results During the median follow-up of 10.0 years, 2547 incident type 2 diabetes cases were documented. Moderate to extreme unhappiness, satisfaction score <= 3, presence of broad depression, and a neuroticism score >= 3 were all significantly and independently associated with an increased risk of diabetes. When considered as a combination indicator, compared with individuals in the highest quartile of the psychological wellbeing score, the fully adjusted hazard ratios (95% CI) of type 2 diabetes were 1.41 (1.21-1.65) in the third quartile, 1.45 (1.24-1.69) in the second quartile, and 1.73 (1.48-2.01) in the lowest quartile. In the stratified analysis, we observed significant interactions between age and physical activity, and type 2 diabetes (P-interaction < .001 and 0.049, respectively). However, there was no significant interaction between the psychological wellbeing score and genetic susceptibility to diabetes (P-interaction = .980). Conclusion Worse overall psychological wellbeing was associated with a significantly increased risk of type 2 diabetes in a dose-response fashion regardless of genetic predisposition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- psychological factors
- type 2 diabetes
- cohort study
- genetics
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sun, Ying
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Yu, Yuefeng
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Zhang, Haojie
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Wang, Bin
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Chen, Chi
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Wang, Yuying
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visa fler...
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Tan, Xiao
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Zhang, Jihui
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Chen, Yi
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Xia, Fangzhen
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Lu, Yingli
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Wang, Ningjian
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet