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Non-alcoholic fatty...
Non-alcoholic fatty liver disease, sleep behaviors, and incident type 2 diabetes
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- Zhang, Haojie (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China.
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- Wang, Yuying (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China.
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- Chen, Chi (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China.
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- Wang, Bin (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China.
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- Chen, Jie (författare)
- Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Sleep Assessment Unit, Hong Kong, Peoples R China.
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- Tan, Xiao (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap,Karolinska Inst, Dept Clin Neurosci, Solna, Sweden.
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- Xia, Fangzhen (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China.
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- Zhang, Jihui (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Peoples R China.
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- Lu, Yingli (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China.
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- Wang, Ningjian (författare)
- Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China.
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Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, Shanghai 200011, Peoples R China Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Sleep Assessment Unit, Hong Kong, Peoples R China. (creator_code:org_t)
- 2022-05-10
- 2022
- Engelska.
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Ingår i: Journal of Gastroenterology and Hepatology. - : John Wiley & Sons. - 0815-9319 .- 1440-1746. ; 37:8, s. 1633-1640
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background and Aim Non-alcoholic fatty liver disease (NAFLD) is associated with incident type 2 diabetes; however, the extent to which NAFLD may confer its risk remains uncertain, especially in Europeans. Emerging evidence suggests that sleep behaviors are linked to NAFLD and diabetes. We aimed to measure whether sleep behaviors modified the association between NAFLD and incident type 2 diabetes. Methods This prospective cohort study included 365 339 participants without type 2 diabetes at baseline in UK Biobank data. Five sleep behaviors, including sleep duration, insomnia, snoring, chronotype, and daytime sleepiness, were collected from the questionnaire. Overall sleep patterns were created by summing the five scores. Liver steatosis was based on the fatty liver index. Results During a median follow up of 11.0 years, we documented 8774 patients with incident type 2 diabetes. NAFLD was significantly associated with increased diabetes risk. Sleeping 7-8 h/day, no insomnia, no self-reported snoring, and no frequent daytime sleepiness were independently associated with incident type 2 diabetes, with a 20%, 18%, 16%, and 31% lower risk, respectively. About 33.8% and 33.5% of type 2 diabetes events in this cohort could be attributed to NAFLD and poor sleep pattern, respectively. Participants with NAFLD and poor sleep pattern showed the highest risk of type 2 diabetes (relative risk 3.17, 95% confidence interval 2.80, 3.59). Sleep pattern (healthy, intermediate, and poor) did not significantly modify the association between NAFLD and type 2 diabetes. However, when studying separately, we found a significant interaction between NAFLD and insomnia on the risk of incident type 2 diabetes (P for interaction = 0.003). Conclusion In this large prospective study, both NAFLD and some sleep behaviors were risk factors for type 2 diabetes. Although overall sleep pattern did not modify the association between NAFLD and type 2 diabetes, certain sleep behavior, especially insomnia, showed the modification effect.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- chronotype
- excessive daytime sleepiness
- fatty liver index
- insomnia
- interaction
- non-alcoholic fatty liver disease
- sleep duration
- sleep pattern
- snoring
- type 2 diabetes
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Till lärosätets databas
- Av författaren/redakt...
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Zhang, Haojie
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Wang, Yuying
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Chen, Chi
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Wang, Bin
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Chen, Jie
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Tan, Xiao
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visa fler...
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Xia, Fangzhen
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Zhang, Jihui
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Lu, Yingli
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Wang, Ningjian
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Journal of Gastr ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet