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Suicide in schizoph...
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Clapham, EricUppsala universitet,Psykiatri
(författare)
Suicide in schizophrenia and adverse events during antipsychotic medication
Förlag, utgivningsår, omfång ...
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Uppsala :Acta Universitatis Upsaliensis,2022
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44 s.
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-485764
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ISBN:9789151316147
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485764URI
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Språk:engelska
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Sammanfattning på:engelska &language:-1_t
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:dok swepub-publicationtype
Serie
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Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,1651-6206 ;1873
Anmärkningar
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This thesis considers side effects and other adverse events during treatment with antipsychotic medication. All included studies use an epidemiological methodology with data from Swedish population-based health registers. The first two studies utilise a nested case-control design, whereas the third and fourth studies rely on cohort designs.The first study considers the impact of extrapyramidal symptoms on suicidality in a schizophrenia spectrum patient group in Stockholm County in Sweden. In this sample, extrapyramidal symptoms are found to be associated with a decreased risk of suicide.The second study involves suicidal communication, blindly extracted from patient records, as risk factors for suicide among patients with schizophrenia spectrum disorders. More severe forms of suicidal ideation and behaviour, such as suicide attempt, are associated with a higher risk of death by suicide, which is consistent with current clinical practice regarding suicide risk assessments.The third study considers the risk of bone fracture during treatment with antipsychotic medications. The study finds that risperidone is not associated with an increased risk of fracture compared with first-generation antipsychotics.The fourth study considers the risk of perimyocarditis and heart failure during treatment with clozapine and the chemically similar medications olanzapine and quetiapine. It finds that clozapine is associated with a substantially elevated risk of perimyocarditis in the short term and a more modest risk of heart failure in the long term, compared with no antipsychotic treatment. Treatment with at least one of olanzapine or quetiapine is not found to be associated with an increased risk of these adverse cardiac events, compared with no antipsychotic medication.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bodén, Robert,1973-Uppsala universitet,Psykiatri(Swepub:uu)robod677
(preses)
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Reutfors, Johan,DocentCentrum för farmakoepidemiologi, Instititutionen för medicin Solna, Karolinska Universitetssjukhuset, Karolinska Institutet
(preses)
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Kieler, Helle,ProfessorCentrum för farmakoepidemiologi, Instititutionen för medicin Solna, Karolinska Universitetssjukhuset, Karolinska Institutet
(preses)
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Werneke, Ursula,DocentInstitutionen för klinisk vetenskap, Umeå universitet
(opponent)
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Uppsala universitetPsykiatri
(creator_code:org_t)
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