Sökning: onr:"swepub:oai:DiVA.org:uu-486353" >
Variability of muri...
Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents
-
- Arrazuria, Rakel (författare)
- Div Microbiol, Paul Ehrlich Inst, Langen, Germany.
-
- Kerscher, Bernhard (författare)
- Div Microbiol, Paul Ehrlich Inst, Langen, Germany.
-
- Huber, Karen E. (författare)
- Div Microbiol, Paul Ehrlich Inst, Langen, Germany.
-
visa fler...
-
- Hoover, Jennifer L. (författare)
- Infect Dis Res Unit, GlaxoSmithKline Pharmaceut, Collegeville, PA, United States.
-
- Lundberg, Carina Vingsbo (författare)
- Statens Serum Inst, Dept Bacteria, Parasites Fungi, Copenhagen, Denmark.
-
- Hansen, Jon Ulf (författare)
- Statens Serum Inst, Dept Bacteria, Parasites Fungi, Copenhagen, Denmark.
-
- Sordello, Sylvie (författare)
- Infect Dis, Evotec, Toulouse, France.
-
- Renard, Stephane (författare)
- Infect Dis, Evotec, Toulouse, France.
-
- Aranzana-Climent, Vincent (författare)
- Uppsala universitet,Institutionen för farmaci
-
- Hughes, Diarmaid, 1956- (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Gribbon, Philip (författare)
- Fraunhofer Inst Translat Med & Pharmacol ITMP, Discovery Res ScreeningPort, Hamburg, Germany.
-
- Friberg, Lena E. (författare)
- Uppsala universitet,Institutionen för farmaci
-
- Bekeredjian-Ding, Isabelle (författare)
- Div Microbiol, Paul Ehrlich Inst, Langen, Germany.;Univ Hosp Bonn, Inst Med Microbiol, Immunol & Parasitol, Bonn, Germany.
-
visa färre...
-
Div Microbiol, Paul Ehrlich Inst, Langen, Germany Infect Dis Res Unit, GlaxoSmithKline Pharmaceut, Collegeville, PA, United States. (creator_code:org_t)
- 2022-09-08
- 2022
- Engelska.
-
Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 13
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Antimicrobial resistance has become one of the greatest threats to human health, and new antibacterial treatments are urgently needed. As a tool to develop novel therapies, animal models are essential to bridge the gap between preclinical and clinical research. However, despite common usage of in vivo models that mimic clinical infection, translational challenges remain high. Standardization of in vivo models is deemed necessary to improve the robustness and reproducibility of preclinical studies and thus translational research. The European Innovative Medicines Initiative (IMI)-funded "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) consortium, aims to develop a standardized, quality-controlled murine pneumonia model for preclinical efficacy testing of novel anti-infective candidates and to improve tools for the translation of preclinical data to the clinic. In this review of murine pneumonia model data published in the last 10 years, we present our findings of considerable variability in the protocols employed for testing the efficacy of antimicrobial compounds using this in vivo model. Based on specific inclusion criteria, fifty-three studies focusing on antimicrobial assessment against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii were reviewed in detail. The data revealed marked differences in the experimental design of the murine pneumonia models employed in the literature. Notably, several differences were observed in variables that are expected to impact the obtained results, such as the immune status of the animals, the age, infection route and sample processing, highlighting the necessity of a standardized model.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- murine pneumonia model
- antimicrobial
- lung infection
- Gram-negative
- PK
- PD
- antimicrobial efficacy studies
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Arrazuria, Rakel
-
Kerscher, Bernha ...
-
Huber, Karen E.
-
Hoover, Jennifer ...
-
Lundberg, Carina ...
-
Hansen, Jon Ulf
-
visa fler...
-
Sordello, Sylvie
-
Renard, Stephane
-
Aranzana-Climent ...
-
Hughes, Diarmaid ...
-
Gribbon, Philip
-
Friberg, Lena E.
-
Bekeredjian-Ding ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Mikrobiologi ino ...
- Artiklar i publikationen
-
Frontiers in Mic ...
- Av lärosätet
-
Uppsala universitet