Sökning: onr:"swepub:oai:DiVA.org:uu-487057" > Dehydration is asso...
Fältnamn | Indikatorer | Metadata |
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000 | 05851naa a2200577 4500 | |
001 | oai:DiVA.org:uu-487057 | |
003 | SwePub | |
008 | 221023s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4870572 URI |
024 | 7 | a https://doi.org/10.1186/s13054-022-04203-w2 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hultström, Michael,d 1978-u Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi,Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.;Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut0 (Swepub:uu)mihul498 |
245 | 1 0 | a Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19 :b a multicenter cohort study |
264 | c 2022-10-21 | |
264 | 1 | b Springer Nature,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: We have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity of the physiological response to dehydration known as aestivation and its relevance for long-term disease outcome in COVID-19.METHODS: The study includes 374 COVID-19 patients from the Pronmed cohort admitted to the ICU at Uppsala University Hospital. Dehydration data was available for 165 of these patients and used for the primary analysis. Validation was performed in Biobanque Québécoise de la COVID-19 (BQC19) using 1052 patients with dehydration data. Dehydration was assessed through estimated osmolality (eOSM = 2Na + 2 K + glucose + urea), and correlated to important endpoints including death, invasive mechanical ventilation, acute kidney injury, and long COVID-19 symptom score grouped by physical or mental.RESULTS: Increasing eOSM was correlated with increasing role of organic osmolytes for eOSM, while the proportion of sodium and potassium of eOSM were inversely correlated to eOSM. Acute outcomes were associated with pronounced dehydration, and physical long-COVID was more strongly associated with dehydration than mental long-COVID after adjustment for age, sex, and disease severity. Metabolomic analysis showed enrichment of amino acids among metabolites that showed an aestivating pattern.CONCLUSIONS: Dehydration during acute COVID-19 infection causes an aestivation response that is associated with protein degradation and physical long-COVID.TRIAL REGISTRATION: The study was registered à priori (clinicaltrials.gov: NCT04316884 registered on 2020-03-13 and NCT04474249 registered on 2020-06-29). | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
653 | a Acute kidney injury | |
653 | a Aestivation | |
653 | a Intensive care medicine | |
653 | a Long-COVID | |
653 | a SARS-CoV-2 | |
653 | a Urea synthesis | |
700 | 1 | a Lipcsey, Miklósu Uppsala universitet,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)milip123 |
700 | 1 | a Morrison, Dave Ru Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Nakanishi, Tomokou Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Butler-Laporte, Guillaumeu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Chen, Yihengu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Yoshiji, Satoshiu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Forgetta, Vincenzou Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Farjoun, Yossiu Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Wallin, Ewau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)ewawa635 |
700 | 1 | a Larsson, Ing-Marie,d 1963-u Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)ingla697 |
700 | 1 | a Larsson, Andersu Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)andlarss |
700 | 1 | a Marton, Adrianau Program in Cardiovascular and Metabolic Disorders, Duke- NUS Medical School, Singapore, Singapore.4 aut |
700 | 1 | a Titze, Jens Marcu Program in Cardiovascular and Metabolic Disorders, Duke- NUS Medical School, Singapore, Singapore.4 aut |
700 | 1 | a Nihlén, Sandrau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)sanho907 |
700 | 1 | a Richards, J Brentu Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.4 aut |
700 | 1 | a Frithiof, Robertu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)robfr118 |
710 | 2 | a Uppsala universitetb Anestesiologi och intensivvård4 org |
773 | 0 | t Critical Cared : Springer Natureg 26q 26x 1364-8535x 1466-609X |
856 | 4 | u https://doi.org/10.1186/s13054-022-04203-wy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1705422/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-487057 |
856 | 4 8 | u https://doi.org/10.1186/s13054-022-04203-w |
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