Sökning: onr:"swepub:oai:DiVA.org:uu-487985" >
Genome-associations...
Genome-associations of extended-spectrum ss-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand
-
- Pires, Joao (författare)
- Swiss Fed Inst Technol, Inst Environm Decis, Hlth Geog & Policy Grp, Zurich, Switzerland.
-
- Huber, Laura (författare)
- Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA.
-
- Hickman, Rachel A. (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
visa fler...
-
- Dellicour, Simon (författare)
- Univ Libre Bruxelles, Spatial Epidemiol Lab SpELL, Brussels, Belgium.;Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst, Louvain, Belgium.
-
- Lunha, Kamonwan (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
-
- Leangapichart, Thongpan (författare)
- Norwegian Vet Inst, Sect Food Safety & AMR, Oslo, Norway.
-
- Jiwakanon, Jatesada (författare)
- Khon Kaen Univ, Res Grp Prevent Technol Livestock, Khon Kaen, Thailand.,Khon Kaen University
-
- Magnusson, Ulf (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
-
- Sunde, Marianne (författare)
- Norwegian Vet Inst, Sect Food Safety & AMR, Oslo, Norway.
-
- Järhult, Josef D., 1975- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
- Van Boeckel, Thomas P. (författare)
- Swiss Fed Inst Technol, Inst Environm Decis, Hlth Geog & Policy Grp, Zurich, Switzerland.;Ctr Dis Dynam Econ & Policy, Washington, DC USA.
-
visa färre...
-
Swiss Fed Inst Technol, Inst Environm Decis, Hlth Geog & Policy Grp, Zurich, Switzerland Auburn Univ, Coll Vet Med, Dept Pathobiol, Auburn, AL 36849 USA. (creator_code:org_t)
-
- 2022-10-20
- 2022
- Engelska.
-
Ingår i: BMC Microbiology. - : BioMed Central (BMC). - 1471-2180. ; 22:1
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://pub.epsilon.... (primary) (Raw object) (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://res.slu.se/i...
-
visa färre...
Abstract
Ämnesord
Stäng
- Thailand is undergoing rapid intensification of livestock production where small subsistence farms and medium sized commercial farms coexist. In medium farms, antimicrobials are prescribed by a veterinarian, whereas in small farms antimicrobial use remains largely unsupervised. The impact of these differences as well as other farming practices on the emergence and composition of antimicrobial resistance genes (ARGs) remains largely unknown. We analyzed 363 genomes of extended-spectrum ss-lactamase producing (ESBL) and/or AmpC producing Escherichia coli recovered from humans and pigs at small and medium farms from the Khon Kaen province, Thailand. We tested for genome-wide associations to identify links between ARGs, host, and farm size. Pig isolates from small farms were associated with mcr and qnr genes conferring resistance to colistin and fluoroquinolones, respectively. In contrast, pig isolates from medium farms were associated with ARGs conferring resistance to drugs commonly used on medium farms (i.e., streptomycin). ESBL plasmids from small farms co-carried ARGs conferring resistance to critically important antimicrobials more frequently compared to plasmid from medium farms. Frequent ARG combinations included bla(CTX-M-55) + qnrS1 (29.8% vs 17.5% in small and medium farms, respectively), bla(CTX-M-55) + qnrS1 + mcr-3.19 (5% vs 0%), bla(CTX-M-14) + qnrS1 (9.3% vs 6.2%), and bla(CTX-M-14) + qnrS1 + mcr-1.1 (3.1% vs 0%). The co-location on plasmids of ARGs conferring resistance to critically important antimicrobials as defined by the World Health Organization is concerning, and actions to curb their spread are urgently needed. Legislation on limiting antimicrobial sales and initiatives to better inform farmers and veterinarians on appropriate antimicrobial usage and farm biosecurity could help reduce antimicrobial use on farms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Patobiologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Pathobiology (hsv//eng)
Nyckelord
- Antimicrobial resistance
- Pig
- Farms
- Antimicrobial use
- Escherichia coli
- ESBL
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Pires, Joao
-
Huber, Laura
-
Hickman, Rachel ...
-
Dellicour, Simon
-
Lunha, Kamonwan
-
Leangapichart, T ...
-
visa fler...
-
Jiwakanon, Jates ...
-
Magnusson, Ulf
-
Sunde, Marianne
-
Järhult, Josef D ...
-
Van Boeckel, Tho ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Mikrobiologi ino ...
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Mikrobiologi
-
- LANTBRUKSVETENSKAPER
-
LANTBRUKSVETENSK ...
-
och Veterinärmedicin
-
och Patobiologi
- Artiklar i publikationen
-
BMC Microbiology
- Av lärosätet
-
Uppsala universitet
-
Sveriges Lantbruksuniversitet