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Open The associatio...
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Kang, Sung-YoonGachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea.
(författare)
Open The association between specific IgE antibodies to component allergens and allergic symptoms on dog and cat exposure among Korean pet exhibition participants
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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Elsevier,2022
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LIBRIS-ID:oai:DiVA.org:uu-488550
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488550URI
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https://doi.org/10.1016/j.waojou.2022.100709DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background: Component resolved diagnostics (CRD) in dog and cat allergy is not sufficiently investigated, especially regarding new components such as Can f 4, Can f 6, and Fel d 7. The purpose of this study is to evaluate the potential role of CRD with new components in predicting allergic symptoms on dog and cat exposure.Methods: Among 552 Korean adults who participated in a pet exhibition and completed questionnaires regarding exposure to dog or cat and allergic symptoms, 522 were venipunctured for measurement of IgE and IgG4 antibody concentration against dog and cat dander extract and underwent skin prick test (SPT). In 238 individuals who were sensitized for both dog and cat dander extract, the dog IgE components (Can f 1-6) and the cat components (Fel d 1/2/4/7) were analyzed.Results: An increasing number of sensitizing components was associated with the likelihood of having any allergic symptoms (P < 0.001 for dog and P < 0.01 for cat), and those of asthma (P < 0.01 for dog and P < 0.05 for cat) and rhinoconjunctivitis (P < 0.001 for dog and P < 0.05 for cat). Pairwise correlation of IgE levels was r = 0.56 (P < 0.001) for Can f 6 and Fel d 4, r = 0.74 (P < 0.001) for Can f 1 and Fel d 7 and r = 0.84 (P < 0.001) for Can f 3 and Fel d 2.Conclusions: Polysensitization to dog and cat allergen components is associated with high likelihood of having allergic symptoms during exposure to dogs and cats. Cross-reactivity between dog and cat allergen components is also identified. CRD has a potential in fine-tuning prediction for allergic symptoms on dog and cat exposure.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Yang, Min-SukSMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea.
(författare)
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Borres, Magnus P,1956-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,ImmunoDiagnost Div, Thermo Fisher Sci, Uppsala, Sweden.(Swepub:uu)magbo385
(författare)
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Andersson, MatsUppsala universitet,Institutionen för kvinnors och barns hälsa
(författare)
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Lee, Sang MinGachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea.;Gachon Univ, Gil Med Ctr, 21 Namdong Daero ,774 Beon Gil, Incheon, South Korea.
(författare)
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Lee, Sang PyoGachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea.;Gachon Univ, Gil Med Ctr, 21 Namdong Daero ,774 Beon Gil, Incheon, South Korea.
(författare)
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Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea.SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:World Allergy Organization Journal: Elsevier15:111939-4551
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