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Cohort profile :
Cohort profile : the Swedish Maternal Microbiome project (SweMaMi) - assessing the dynamic associations between the microbiome and maternal and neonatal adverse events
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- Fransson, Emma, PhD, 1973- (författare)
- Karolinska Institutet,Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Gudnadottir, Unnur (författare)
- Karolinska Institutet
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- Hugerth, Luisa W. (författare)
- Karolinska Institutet
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- Itzel, Eva Wiberg (författare)
- Sodersjukhuset AB, Dept Obstet & Gynecol, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.
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- Hamsten, Marica (författare)
- Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Boulund, Fredrik (författare)
- Karolinska Institutet
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- Pennhag, Alexandra (författare)
- Karolinska Institutet
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- Du, Juan (författare)
- Karolinska Institutet
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- Schuppe-Koistinen, Ina (författare)
- Karolinska Institutet
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- Brusselaers, Nele (författare)
- Karolinska Institutet
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- Engstrand, Lars (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-10-26
- 2022
- Engelska.
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 12:10
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose The Swedish Maternal Microbiome (SweMaMi) project was initiated to better understand the dynamics of the microbiome in pregnancy, with longitudinal microbiome sampling, shotgun metagenomics, extensive questionnaires and health registry linkage. Participants Pregnant women were recruited before the 20th gestational week during 2017-2021 in Sweden. In total, 5439 pregnancies (5193 unique women) were included. For 3973 pregnancies (73%), samples were provided at baseline, and for 3141 (58%) at all three timepoints (second and third trimester and postpartum). In total, 38 591 maternal microbiome samples (vaginal, faecal and saliva) and 3109 infant faecal samples were collected. Questionnaires were used to collect information on general, reproductive and mental health, diet and lifestyle, complemented by linkage to the nationwide health registries, also used to follow up the health of the offspring (up to age 10). Findings to date The cohort is fairly representative for the total Swedish pregnant population (data from 2019), with 41% first-time mothers. Women with university level education, born in Sweden, with normal body mass index, not using tobacco-products and aged 30-34 years were slightly over-represented. Future plans The sample and data collection were finalised in November 2021. The next steps are the characterisation of the microbial DNA and linkage to the health and demographic information from the questionnaires and registries. The role of the microbiome on maternal and neonatal outcomes and early-childhood diseases will be explored (including preterm birth, miscarriage) and the role and interaction of other risk factors and confounders (including endometriosis, polycystic ovarian syndrome, diet, drug use). This is currently among the largest pregnancy cohorts in the world with longitudinal design and detailed and standardised microbiome sampling enabling follow-up of both mothers and children. The findings are expected to contribute greatly to the field of reproductive health focusing on pregnancy and neonatal outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- fetal medicine
- maternal medicine
- bacteriology
- microbiology
- public health
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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BMJ Open
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Till lärosätets databas
- Av författaren/redakt...
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Fransson, Emma, ...
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Gudnadottir, Unn ...
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Hugerth, Luisa W ...
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Itzel, Eva Wiber ...
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Hamsten, Marica
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Boulund, Fredrik
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Pennhag, Alexand ...
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Du, Juan
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Schuppe-Koistine ...
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Brusselaers, Nel ...
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Engstrand, Lars
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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BMJ Open
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet